Repurposing Screens of FDA-Approved Drugs Identify 29 Inhibitors of SARS-CoV-2
COVID-19, caused by the novel coronavirus SARS-CoV-2, has spread globally and caused serious social and economic problems. The WHO has declared this outbreak a pandemic. Currently, there are no approved vaccines or antiviral drugs that prevent SARS-CoV-2 infection. Drugs already approved for clinical use would be ideal candidates for rapid development as COVID-19 treatments. In this work, we screened 1,473 FDA-approved drugs to identify inhibitors of SARS-CoV-2 infection using cell-based assays. The antiviral activity of each compound was measured based on the immunofluorescent staining of infected cells using anti-dsRNA antibody. Twenty-nine drugs among those tested showed antiviral activity against SARS-CoV-2. We report this new list of inhibitors to quickly provide basic information for consideration in developing potential therapies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Journal of microbiology and biotechnology - 30(2020), 12 vom: 28. Dez., Seite 1843-1853 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ku, Keun Bon [VerfasserIn] |
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| Links: |
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| Themen: |
Antiviral Agents |
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| Anmerkungen: |
Date Completed 05.01.2021 Date Revised 14.12.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.4014/jmb.2009.09009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31771063X |
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| 520 | |a COVID-19, caused by the novel coronavirus SARS-CoV-2, has spread globally and caused serious social and economic problems. The WHO has declared this outbreak a pandemic. Currently, there are no approved vaccines or antiviral drugs that prevent SARS-CoV-2 infection. Drugs already approved for clinical use would be ideal candidates for rapid development as COVID-19 treatments. In this work, we screened 1,473 FDA-approved drugs to identify inhibitors of SARS-CoV-2 infection using cell-based assays. The antiviral activity of each compound was measured based on the immunofluorescent staining of infected cells using anti-dsRNA antibody. Twenty-nine drugs among those tested showed antiviral activity against SARS-CoV-2. We report this new list of inhibitors to quickly provide basic information for consideration in developing potential therapies | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a FDA-approved drugs | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a repurposing screens | |
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| 700 | 1 | |a Kim, Hae Soo |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Bum-Tae |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Seong-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Chonsaeng |e verfasserin |4 aut | |
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