Serial Evaluation of Haemostasis Following Acute Trauma Using Rotational Thromboelastometry in Dogs
Thieme. All rights reserved..
OBJECTIVE: The aim of this study was to describe the coagulation status of traumatized dogs over the first 24 hours after admission.
STUDY DESIGN: In 33 dogs presenting within 6 hours after trauma blood was sampled for rotational thromboelastometry (ROTEM), thrombocyte number and venous blood gas analysis at presentation and 6 and 24 hours thereafter. At each time point, dogs were defined as hypo-, normo- or hypercoagulable based on extrinsic, intrinsic and fibrinogen ROTEM profiles.
RESULTS: Significantly more dogs (11/33) presented hypocoagulable compared with 6 hours (p = 0.046) and 24 hours (p = 0.008) thereafter and none presented hypercoagulable. Significantly more dogs were hypercoagulable (6/23, p = 0.014) and no dog was hypocoagulable at 24 hours compared with presentation. All evaluated ROTEM parameters except maximum lysis were significantly more hypocoagulable at presentation compared with 24 hours thereafter.
CONCLUSION: Hypocoagulability is more common in acutely traumatized dogs than previously described. Dogs were hypo- or normocoagulable at presentation and the coagulation status changed to normo- or hypercoagulability over the first 24 hours. Clotting times, clot formation and clot firmness but not clot lysis were significantly altered at presentation compared with 24 hours and fibrinogen concentration or function may play an important role in the dynamic change of coagulation state over time.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Veterinary and comparative orthopaedics and traumatology : V.C.O.T - 34(2021), 3 vom: 16. Mai, Seite 206-213 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Herrero, Yaiza [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 25.11.2021 Date Revised 25.11.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1055/s-0040-1719167 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317696823 |
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| 100 | 1 | |a Herrero, Yaiza |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serial Evaluation of Haemostasis Following Acute Trauma Using Rotational Thromboelastometry in Dogs |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 25.11.2021 | ||
| 500 | |a Date Revised 25.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Thieme. All rights reserved. | ||
| 520 | |a OBJECTIVE: The aim of this study was to describe the coagulation status of traumatized dogs over the first 24 hours after admission | ||
| 520 | |a STUDY DESIGN: In 33 dogs presenting within 6 hours after trauma blood was sampled for rotational thromboelastometry (ROTEM), thrombocyte number and venous blood gas analysis at presentation and 6 and 24 hours thereafter. At each time point, dogs were defined as hypo-, normo- or hypercoagulable based on extrinsic, intrinsic and fibrinogen ROTEM profiles | ||
| 520 | |a RESULTS: Significantly more dogs (11/33) presented hypocoagulable compared with 6 hours (p = 0.046) and 24 hours (p = 0.008) thereafter and none presented hypercoagulable. Significantly more dogs were hypercoagulable (6/23, p = 0.014) and no dog was hypocoagulable at 24 hours compared with presentation. All evaluated ROTEM parameters except maximum lysis were significantly more hypocoagulable at presentation compared with 24 hours thereafter | ||
| 520 | |a CONCLUSION: Hypocoagulability is more common in acutely traumatized dogs than previously described. Dogs were hypo- or normocoagulable at presentation and the coagulation status changed to normo- or hypercoagulability over the first 24 hours. Clotting times, clot formation and clot firmness but not clot lysis were significantly altered at presentation compared with 24 hours and fibrinogen concentration or function may play an important role in the dynamic change of coagulation state over time | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Schefer, Rahel Jud |e verfasserin |4 aut | |
| 700 | 1 | |a Muri, Benjamin M |e verfasserin |4 aut | |
| 700 | 1 | |a Sigrist, Nadja E |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Veterinary and comparative orthopaedics and traumatology : V.C.O.T |d 1996 |g 34(2021), 3 vom: 16. Mai, Seite 206-213 |w (DE-627)NLM088735591 |x 2567-6911 |7 nnns |
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