Depression and cognitive function in early multiple sclerosis : Multitasking is more sensitive than traditional assessments
BACKGROUND: Persons with multiple sclerosis (MS) and depression symptoms report real-world cognitive difficulties that may be missed by laboratory cognitive tests.
OBJECTIVE: To examine the relationship of depressive symptoms to cognitive monotasking versus multitasking in early MS.
METHOD: Persons with early MS (n = 185; ⩽5 years diagnosed) reported mood, completed monotasking and multitasking cognitive tests, and received high-resolution 3.0 T magnetic resonance imaging (MRI). Partial correlations analyzed associations between mood and cognition, controlling for age, sex, estimated premorbid IQ, T2 lesion volume, and normalized gray matter volume.
RESULTS: Depression symptoms were more related to worse cognitive multitasking (-0.353, p < 0.001) than monotasking (r = -0.189, p = 0.011). There was a significant albeit weaker link to cognitive efficiency composite score (r = -0.281, p < 0.001), but not composite memory (r = -0.036, p > 0.50). Findings were replicated with a second depression measure. Multitasking was worse in patients with at least mild depression than both patients with no/minimal depression and healthy controls. Multitasking was not related to mood in healthy controls.
CONCLUSIONS: Depression symptoms are linked to cognitive multitasking in early MS; standard monotasking cognitive assessments appear less sensitive to depression-related cognition. Further investigation should determine directionality and mechanisms of this relationship, with the goal of enhancing treatment for cognitive dysfunction and depression in MS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Multiple sclerosis (Houndmills, Basingstoke, England) - 27(2021), 8 vom: 16. Juli, Seite 1276-1283 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Glukhovsky, Lisa [VerfasserIn] |
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| Links: |
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| Themen: |
Cognition |
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| Anmerkungen: |
Date Completed 27.09.2021 Date Revised 31.07.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/1352458520958359 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317638041 |
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| 100 | 1 | |a Glukhovsky, Lisa |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Depression and cognitive function in early multiple sclerosis |b Multitasking is more sensitive than traditional assessments |
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| 500 | |a Date Completed 27.09.2021 | ||
| 500 | |a Date Revised 31.07.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Persons with multiple sclerosis (MS) and depression symptoms report real-world cognitive difficulties that may be missed by laboratory cognitive tests | ||
| 520 | |a OBJECTIVE: To examine the relationship of depressive symptoms to cognitive monotasking versus multitasking in early MS | ||
| 520 | |a METHOD: Persons with early MS (n = 185; ⩽5 years diagnosed) reported mood, completed monotasking and multitasking cognitive tests, and received high-resolution 3.0 T magnetic resonance imaging (MRI). Partial correlations analyzed associations between mood and cognition, controlling for age, sex, estimated premorbid IQ, T2 lesion volume, and normalized gray matter volume | ||
| 520 | |a RESULTS: Depression symptoms were more related to worse cognitive multitasking (-0.353, p < 0.001) than monotasking (r = -0.189, p = 0.011). There was a significant albeit weaker link to cognitive efficiency composite score (r = -0.281, p < 0.001), but not composite memory (r = -0.036, p > 0.50). Findings were replicated with a second depression measure. Multitasking was worse in patients with at least mild depression than both patients with no/minimal depression and healthy controls. Multitasking was not related to mood in healthy controls | ||
| 520 | |a CONCLUSIONS: Depression symptoms are linked to cognitive multitasking in early MS; standard monotasking cognitive assessments appear less sensitive to depression-related cognition. Further investigation should determine directionality and mechanisms of this relationship, with the goal of enhancing treatment for cognitive dysfunction and depression in MS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 4 | |a cognition | |
| 650 | 4 | |a depression | |
| 650 | 4 | |a executive function | |
| 650 | 4 | |a mood | |
| 700 | 1 | |a Kurz, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Brandstadter, Rachel |e verfasserin |4 aut | |
| 700 | 1 | |a Leavitt, Victoria M |e verfasserin |4 aut | |
| 700 | 1 | |a Krieger, Stephen |e verfasserin |4 aut | |
| 700 | 1 | |a Fabian, Michelle |e verfasserin |4 aut | |
| 700 | 1 | |a Katz Sand, Ilana |e verfasserin |4 aut | |
| 700 | 1 | |a Klineova, Sylvia |e verfasserin |4 aut | |
| 700 | 1 | |a Riley, Claire S |e verfasserin |4 aut | |
| 700 | 1 | |a Lublin, Fred D |e verfasserin |4 aut | |
| 700 | 1 | |a Miller, Aaron E |e verfasserin |4 aut | |
| 700 | 1 | |a Sumowski, James F |e verfasserin |4 aut | |
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