Cerebral Venous Sinus Thrombosis in COVID-19 Infection : A Case Series and Review of The Literature
Copyright © 2020 Elsevier Inc. All rights reserved..
SARS-CoV-2, the virus responsible for novel Coronavirus (COVID-19) infection, has recently been associated with a myriad of hematologic derangements; in particular, an unusually high incidence of venous thromboembolism has been reported in patients with COVID-19 infection. It is postulated that either the cytokine storm induced by the viral infection or endothelial damage caused by viral binding to the ACE-2 receptor may activate a cascade leading to a hypercoaguable state. Although pulmonary embolism and deep venous thrombosis have been well described in patients with COVID-19 infection, there is a paucity of literature on cerebral venous sinus thrombosis (cVST) associated with COVID-19 infection. cVST is an uncommon etiology of stroke and has a higher occurrence in women and young people. We report a series of three patients at our institution with confirmed COVID-19 infection and venous sinus thrombosis, two of whom were male and one female. These cases fall outside the typical demographic of patients with cVST, potentially attributable to COVID-19 induced hypercoaguability. This illustrates the importance of maintaining a high index of suspicion for cVST in patients with COVID-19 infection, particularly those with unexplained cerebral hemorrhage, or infarcts with an atypical pattern for arterial occlusive disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 30(2021), 1 vom: 30. Jan., Seite 105434 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dakay, Katarina [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 23.12.2020 Date Revised 06.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jstrokecerebrovasdis.2020.105434 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317575236 |
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| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a SARS-CoV-2, the virus responsible for novel Coronavirus (COVID-19) infection, has recently been associated with a myriad of hematologic derangements; in particular, an unusually high incidence of venous thromboembolism has been reported in patients with COVID-19 infection. It is postulated that either the cytokine storm induced by the viral infection or endothelial damage caused by viral binding to the ACE-2 receptor may activate a cascade leading to a hypercoaguable state. Although pulmonary embolism and deep venous thrombosis have been well described in patients with COVID-19 infection, there is a paucity of literature on cerebral venous sinus thrombosis (cVST) associated with COVID-19 infection. cVST is an uncommon etiology of stroke and has a higher occurrence in women and young people. We report a series of three patients at our institution with confirmed COVID-19 infection and venous sinus thrombosis, two of whom were male and one female. These cases fall outside the typical demographic of patients with cVST, potentially attributable to COVID-19 induced hypercoaguability. This illustrates the importance of maintaining a high index of suspicion for cVST in patients with COVID-19 infection, particularly those with unexplained cerebral hemorrhage, or infarcts with an atypical pattern for arterial occlusive disease | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Coronavirus | |
| 650 | 4 | |a Hypercoaguability | |
| 650 | 4 | |a Stroke | |
| 650 | 4 | |a Venous sinus thrombosis | |
| 650 | 4 | |a Venous thromboembolism | |
| 700 | 1 | |a Cooper, Jared |e verfasserin |4 aut | |
| 700 | 1 | |a Bloomfield, Jessica |e verfasserin |4 aut | |
| 700 | 1 | |a Overby, Philip |e verfasserin |4 aut | |
| 700 | 1 | |a Mayer, Stephan A |e verfasserin |4 aut | |
| 700 | 1 | |a Nuoman, Rolla |e verfasserin |4 aut | |
| 700 | 1 | |a Sahni, Ramandeep |e verfasserin |4 aut | |
| 700 | 1 | |a Gulko, Edwin |e verfasserin |4 aut | |
| 700 | 1 | |a Kaur, Gurmeen |e verfasserin |4 aut | |
| 700 | 1 | |a Santarelli, Justin |e verfasserin |4 aut | |
| 700 | 1 | |a Gandhi, Chirag D |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Mufti, Fawaz |e verfasserin |4 aut | |
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