Cross-Sectional and Longitudinal Associations Between Plasma Neurodegenerative Biomarkers and Physical Performance Among Community-Dwelling Older Adults
© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
BACKGROUND: Plasma amyloid-beta (Aβ), neurofilament light chain (NfL), and progranulin (PGRN) have been related to multiple neurodegenerative conditions that might affect physical performance. The aim of this study was to explore the relationship between these plasma neurodegenerative markers and physical performance among community-dwelling older adults.
METHODS: Five hundred and seven older adults (aged 76 ± 5 years) previously recruited in the Multidomain Alzheimer's Preventive Trial, and had received blood and physical performance tests, were included in this study. Plasma Aβ (Aβ 42/Aβ 40 ratio), NfL, and PGRN levels were measured. Physical performance was assessed by handgrip strength and the Short Physical Performance Battery (combining gait speed, chair stands, and balance tests). Physical performance measured at the same time point and after the blood tests were used. Mixed-effect linear models were performed with age, sex, allocation to Multidomain Alzheimer's Preventive Trial group, body mass index, and Mini-Mental State Examination score as covariates.
RESULTS: The mean values of Aβ 42/Aβ 40 ratio, NfL, and PGRN were 0.11, 84.06 pg/mL, and 45.43 ng/mL, respectively. At the cross-sectional level, higher plasma NfL was associated with a lower Short Physical Performance Battery score (β = -0.004, 95% CI [-0.007, -0.001]). At the longitudinal level, higher PGRN levels were associated with decreasing handgrip strength over time (β = -0.02, 95% CI [-0.04, -0.007]). All the other associations were statistically nonsignificant.
CONCLUSION: Our findings suggest the possibility of using plasma NfL and PGRN as markers of physical performance in older adults.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
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| Enthalten in: |
The journals of gerontology. Series A, Biological sciences and medical sciences - 76(2021), 10 vom: 13. Sept., Seite 1874-1881 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
He, Lingxiao [VerfasserIn] |
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| Links: |
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| Themen: |
Amyloid beta-Peptides |
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| Anmerkungen: |
Date Completed 07.02.2022 Date Revised 23.02.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/gerona/glaa284 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317539280 |
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| 100 | 1 | |a He, Lingxiao |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cross-Sectional and Longitudinal Associations Between Plasma Neurodegenerative Biomarkers and Physical Performance Among Community-Dwelling Older Adults |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 23.02.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: Plasma amyloid-beta (Aβ), neurofilament light chain (NfL), and progranulin (PGRN) have been related to multiple neurodegenerative conditions that might affect physical performance. The aim of this study was to explore the relationship between these plasma neurodegenerative markers and physical performance among community-dwelling older adults | ||
| 520 | |a METHODS: Five hundred and seven older adults (aged 76 ± 5 years) previously recruited in the Multidomain Alzheimer's Preventive Trial, and had received blood and physical performance tests, were included in this study. Plasma Aβ (Aβ 42/Aβ 40 ratio), NfL, and PGRN levels were measured. Physical performance was assessed by handgrip strength and the Short Physical Performance Battery (combining gait speed, chair stands, and balance tests). Physical performance measured at the same time point and after the blood tests were used. Mixed-effect linear models were performed with age, sex, allocation to Multidomain Alzheimer's Preventive Trial group, body mass index, and Mini-Mental State Examination score as covariates | ||
| 520 | |a RESULTS: The mean values of Aβ 42/Aβ 40 ratio, NfL, and PGRN were 0.11, 84.06 pg/mL, and 45.43 ng/mL, respectively. At the cross-sectional level, higher plasma NfL was associated with a lower Short Physical Performance Battery score (β = -0.004, 95% CI [-0.007, -0.001]). At the longitudinal level, higher PGRN levels were associated with decreasing handgrip strength over time (β = -0.02, 95% CI [-0.04, -0.007]). All the other associations were statistically nonsignificant | ||
| 520 | |a CONCLUSION: Our findings suggest the possibility of using plasma NfL and PGRN as markers of physical performance in older adults | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Amyloid-beta ratio | |
| 650 | 4 | |a Handgrip strength | |
| 650 | 4 | |a Neurofilament light chain | |
| 650 | 4 | |a Progranulin | |
| 650 | 4 | |a SPPB | |
| 650 | 7 | |a Amyloid beta-Peptides |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 700 | 1 | |a de Souto Barreto, Philipe |e verfasserin |4 aut | |
| 700 | 1 | |a Giudici, Kelly V |e verfasserin |4 aut | |
| 700 | 1 | |a Aggarwal, Geetika |e verfasserin |4 aut | |
| 700 | 1 | |a Nguyen, Andrew D |e verfasserin |4 aut | |
| 700 | 1 | |a Morley, John E |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Bateman, Randall J |e verfasserin |4 aut | |
| 700 | 1 | |a Vellas, Bruno |e verfasserin |4 aut | |
| 700 | 0 | |a MAPT/DSA Group |e verfasserin |4 aut | |
| 700 | 1 | |a Vellas, Bruno |e investigator |4 oth | |
| 700 | 1 | |a Guyonnet, Sophie |e investigator |4 oth | |
| 700 | 1 | |a Carrié, Isabelle |e investigator |4 oth | |
| 700 | 1 | |a Brigitte, Lauréane |e investigator |4 oth | |
| 700 | 1 | |a Faisant, Catherine |e investigator |4 oth | |
| 700 | 1 | |a Lala, Françoise |e investigator |4 oth | |
| 700 | 1 | |a Delrieu, Julien |e investigator |4 oth | |
| 700 | 1 | |a Villars, Hélène |e investigator |4 oth | |
| 700 | 1 | |a Combrouze, Emeline |e investigator |4 oth | |
| 700 | 1 | |a Badufle, Carole |e investigator |4 oth | |
| 700 | 1 | |a Zueras, Audrey |e investigator |4 oth | |
| 700 | 1 | |a Andrieu, Sandrine |e investigator |4 oth | |
| 700 | 1 | |a Cantet, Christelle |e investigator |4 oth | |
| 700 | 1 | |a Morin, Christophe |e investigator |4 oth | |
| 700 | 1 | |a Abellan Van Kan, Gabor |e investigator |4 oth | |
| 700 | 1 | |a Dupuy, Charlotte |e investigator |4 oth | |
| 700 | 1 | |a Rolland, Yves |e investigator |4 oth | |
| 700 | 1 | |a Caillaud, Céline |e investigator |4 oth | |
| 700 | 1 | |a Ousset, Pierre-Jean |e investigator |4 oth | |
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