Night-restricted feeding improves locomotor activity rhythm and modulates nutrient utilization to accelerate growth in rabbits
© 2020 Federation of American Societies for Experimental Biology..
An unfavorable lifestyle disrupts the circadian rhythm, leading to metabolic dysfunction in adult humans and animals. Increasing evidence suggests that night-restricted feeding (NRF) can effectively prevent ectopic fat deposition caused by circadian rhythm disruption, and reduce the risk of metabolic diseases. However, previous studies have mainly focused on the prevention of obesity in adults by regulating dietary patterns, whereas limited attention has been paid to the effect of NRF on metabolism during growth and development. Here, we used weaning rabbits as models and found that NRF increased body weight gain without increasing feed intake, and promoted insulin-mediated protein synthesis through the mTOR/S6K pathway and muscle formation by upregulating MYOG. NRF improved the circadian clock, promoted PDH-regulated glycolysis and CPT1B-regulated fatty-acid β-oxidation, and reduced fat content in the serum and muscles. In addition, NRF-induced body temperature oscillation might be partly responsible for the improvement in the circadian clock and insulin sensitivity. Time-restricted feeding could be used as a nondrug intervention to prevent obesity and accelerate growth in adolescents.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 35(2021), 1 vom: 01. Jan., Seite e21166 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guo, Yao [VerfasserIn] |
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| Links: |
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| Themen: |
Adolescent obesity |
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| Anmerkungen: |
Date Completed 15.06.2021 Date Revised 15.06.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1096/fj.202001265RR |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317524224 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 Federation of American Societies for Experimental Biology. | ||
| 520 | |a An unfavorable lifestyle disrupts the circadian rhythm, leading to metabolic dysfunction in adult humans and animals. Increasing evidence suggests that night-restricted feeding (NRF) can effectively prevent ectopic fat deposition caused by circadian rhythm disruption, and reduce the risk of metabolic diseases. However, previous studies have mainly focused on the prevention of obesity in adults by regulating dietary patterns, whereas limited attention has been paid to the effect of NRF on metabolism during growth and development. Here, we used weaning rabbits as models and found that NRF increased body weight gain without increasing feed intake, and promoted insulin-mediated protein synthesis through the mTOR/S6K pathway and muscle formation by upregulating MYOG. NRF improved the circadian clock, promoted PDH-regulated glycolysis and CPT1B-regulated fatty-acid β-oxidation, and reduced fat content in the serum and muscles. In addition, NRF-induced body temperature oscillation might be partly responsible for the improvement in the circadian clock and insulin sensitivity. Time-restricted feeding could be used as a nondrug intervention to prevent obesity and accelerate growth in adolescents | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a adolescent obesity | |
| 650 | 4 | |a circadian rhythm | |
| 650 | 4 | |a core body temperature | |
| 650 | 4 | |a muscle growth | |
| 650 | 4 | |a night-restricted feeding | |
| 700 | 1 | |a Wang, Qiang-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Ke-Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Chun-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Qin |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zhong-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Shan, Chun-Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Peng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Mei-Zhi |e verfasserin |4 aut | |
| 700 | 1 | |a An, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Jian-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Zhong-Hong |e verfasserin |4 aut | |
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