The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease
Copyright © 2020 Elsevier Ltd. All rights reserved..
To maintain homeostasis, an organism must detect and resolve sterile tissue damage. The NLRP3 inflammasome coordinates such processes to clear tissue damage and induce repair. Dysregulated NLRP3 inflammasome activity, however, drives many conditions including Alzheimer's disease (AD). Recent reports posit that β-amyloid and tau aggregates trigger destructive NLRP3 inflammasome signalling in the brain, leading to AD pathophysiology and cognitive decline. Other endogenous molecules (e.g. TNF, ATP, serum amyloid A), as well as dysbiosis, can induce peripheral or central inflammation and thereby promote microglial NLRP3 inflammasome signalling and resultant AD. The NLRP3 inflammasome is thus emerging as a critical driver of sterile neuroinflammation and the resultant pathogenesis and progression of AD.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:68 |
---|---|
Enthalten in: |
Current opinion in immunology - 68(2021) vom: 25. Feb., Seite 116-124 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Milner, Mark T [VerfasserIn] |
---|
Links: |
---|
Themen: |
Inflammasomes |
---|
Anmerkungen: |
Date Completed 07.12.2021 Date Revised 14.12.2021 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.coi.2020.10.011 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM317488643 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM317488643 | ||
003 | DE-627 | ||
005 | 20231225163356.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.coi.2020.10.011 |2 doi | |
028 | 5 | 2 | |a pubmed24n1058.xml |
035 | |a (DE-627)NLM317488643 | ||
035 | |a (NLM)33181351 | ||
035 | |a (PII)S0952-7915(20)30110-2 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Milner, Mark T |e verfasserin |4 aut | |
245 | 1 | 4 | |a The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 07.12.2021 | ||
500 | |a Date Revised 14.12.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2020 Elsevier Ltd. All rights reserved. | ||
520 | |a To maintain homeostasis, an organism must detect and resolve sterile tissue damage. The NLRP3 inflammasome coordinates such processes to clear tissue damage and induce repair. Dysregulated NLRP3 inflammasome activity, however, drives many conditions including Alzheimer's disease (AD). Recent reports posit that β-amyloid and tau aggregates trigger destructive NLRP3 inflammasome signalling in the brain, leading to AD pathophysiology and cognitive decline. Other endogenous molecules (e.g. TNF, ATP, serum amyloid A), as well as dysbiosis, can induce peripheral or central inflammation and thereby promote microglial NLRP3 inflammasome signalling and resultant AD. The NLRP3 inflammasome is thus emerging as a critical driver of sterile neuroinflammation and the resultant pathogenesis and progression of AD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Review | |
650 | 7 | |a Inflammasomes |2 NLM | |
650 | 7 | |a NLR Family, Pyrin Domain-Containing 3 Protein |2 NLM | |
700 | 1 | |a Maddugoda, Madhavi |e verfasserin |4 aut | |
700 | 1 | |a Götz, Jürgen |e verfasserin |4 aut | |
700 | 1 | |a Burgener, Sabrina S |e verfasserin |4 aut | |
700 | 1 | |a Schroder, Kate |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Current opinion in immunology |d 1989-1990 |g 68(2021) vom: 25. Feb., Seite 116-124 |w (DE-627)NLM01261923X |x 1879-0372 |7 nnns |
773 | 1 | 8 | |g volume:68 |g year:2021 |g day:25 |g month:02 |g pages:116-124 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.coi.2020.10.011 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 68 |j 2021 |b 25 |c 02 |h 116-124 |