Zebrafish Models to Study Inflammasome-Mediated Regulation of Hematopoiesis
Copyright © 2020 Elsevier Ltd. All rights reserved..
Hematopoiesis is a complex process through which immature bone marrow precursor cells mature into all types of blood cells. Although the association of hematopoietic lineage bias (including anemia and neutrophilia) with chronic inflammatory diseases has long been appreciated, the causes involved are obscure. Recently, cytosolic multiprotein inflammasome complexes were shown to activate inflammatory and immune responses, and directly regulate hematopoiesis in zebrafish models; this was deemed to occur via cleavage and inactivation of the master erythroid transcription factor GATA1. Herein summarized are the zebrafish models that are currently available to study this unappreciated role of inflammasome-mediated regulation of hematopoiesis. Novel putative therapeutic strategies, for the treatment of hematopoietic alterations associated with chronic inflammatory diseases in humans, are also proposed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Trends in immunology - 41(2020), 12 vom: 30. Dez., Seite 1116-1127 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rodríguez-Ruiz, Lola [VerfasserIn] |
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| Links: |
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| Themen: |
Anemia |
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| Anmerkungen: |
Date Completed 17.03.2021 Date Revised 17.03.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.it.2020.10.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317301012 |
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| 520 | |a Hematopoiesis is a complex process through which immature bone marrow precursor cells mature into all types of blood cells. Although the association of hematopoietic lineage bias (including anemia and neutrophilia) with chronic inflammatory diseases has long been appreciated, the causes involved are obscure. Recently, cytosolic multiprotein inflammasome complexes were shown to activate inflammatory and immune responses, and directly regulate hematopoiesis in zebrafish models; this was deemed to occur via cleavage and inactivation of the master erythroid transcription factor GATA1. Herein summarized are the zebrafish models that are currently available to study this unappreciated role of inflammasome-mediated regulation of hematopoiesis. Novel putative therapeutic strategies, for the treatment of hematopoietic alterations associated with chronic inflammatory diseases in humans, are also proposed | ||
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| 700 | 1 | |a Lozano-Gil, Juan M |e verfasserin |4 aut | |
| 700 | 1 | |a Lachaud, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Mesa-Del-Castillo, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Cayuela, María L |e verfasserin |4 aut | |
| 700 | 1 | |a García-Moreno, Diana |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Oliva, Ana B |e verfasserin |4 aut | |
| 700 | 1 | |a Mulero, Victoriano |e verfasserin |4 aut | |
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