Self-reported symptoms from exposure to Covid-19 provide support to clinical diagnosis, triage and prognosis : An exploratory analysis
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved..
BACKGROUND: Symptomatic COVID-19 is prevalent in the community. We identify factors indicating COVID-19 positivity in non-hospitalized patients and prognosticators of moderate-to-severe disease.
METHODS: Appeals conducted in April-June 2020 in social media, collaborating medical societies and patient advocacy groups recruited 20,476 participants ≥18 years who believed they had COVID-19 exposure. Volunteers consented on-line and reported height, weight, concomitant illnesses, medication and supplement use, residential, occupational or community COVID-19 exposure, symptoms and symptom severity on a 4-point scale. Of the 12,117 curated analytic population 2279 reported a COVID-19 viral test result: 865 positive (COVID+) and 1414 negative (COVID-).
RESULTS: The triad of anosmia, ageusia and fever best distinguished COVID+ from COVID-participants (OR 6.07, 95% CI: 4.39 to 8.47). COVID + subjects with BMI≥30, concomitant respiratory disorders or an organ transplant had increased risk of moderate-to- severe dyspnoea. Race and anti-autoimmunity medication did not affect moderate-to-severe dyspnea risk.
CONCLUSIONS: The triad of anosmia, ageusia and fever differentiates COVID-19. Elevated risks of severe symptoms outside the hospital were most evident among the obese and those with pulmonary comorbidity. Race and use of medication for autoimmune disease did not predict severe disease. These findings should facilitate rapid COVID-19 diagnosis and triage in settings without testing.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
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| Enthalten in: |
Travel medicine and infectious disease - 38(2020) vom: 16. Nov., Seite 101909 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dreyer, Nancy A [VerfasserIn] |
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| Links: |
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| Themen: |
Ageusia |
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| Anmerkungen: |
Date Completed 05.01.2021 Date Revised 10.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.tmaid.2020.101909 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317206524 |
|---|
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| 100 | 1 | |a Dreyer, Nancy A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Self-reported symptoms from exposure to Covid-19 provide support to clinical diagnosis, triage and prognosis |b An exploratory analysis |
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| 500 | |a Date Completed 05.01.2021 | ||
| 500 | |a Date Revised 10.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a BACKGROUND: Symptomatic COVID-19 is prevalent in the community. We identify factors indicating COVID-19 positivity in non-hospitalized patients and prognosticators of moderate-to-severe disease | ||
| 520 | |a METHODS: Appeals conducted in April-June 2020 in social media, collaborating medical societies and patient advocacy groups recruited 20,476 participants ≥18 years who believed they had COVID-19 exposure. Volunteers consented on-line and reported height, weight, concomitant illnesses, medication and supplement use, residential, occupational or community COVID-19 exposure, symptoms and symptom severity on a 4-point scale. Of the 12,117 curated analytic population 2279 reported a COVID-19 viral test result: 865 positive (COVID+) and 1414 negative (COVID-) | ||
| 520 | |a RESULTS: The triad of anosmia, ageusia and fever best distinguished COVID+ from COVID-participants (OR 6.07, 95% CI: 4.39 to 8.47). COVID + subjects with BMI≥30, concomitant respiratory disorders or an organ transplant had increased risk of moderate-to- severe dyspnoea. Race and anti-autoimmunity medication did not affect moderate-to-severe dyspnea risk | ||
| 520 | |a CONCLUSIONS: The triad of anosmia, ageusia and fever differentiates COVID-19. Elevated risks of severe symptoms outside the hospital were most evident among the obese and those with pulmonary comorbidity. Race and use of medication for autoimmune disease did not predict severe disease. These findings should facilitate rapid COVID-19 diagnosis and triage in settings without testing | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Ageusia | |
| 650 | 4 | |a Anosmia | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Direct to patient | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Infectious disease | |
| 700 | 1 | |a Reynolds, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a DeFilippo Mack, Christina |e verfasserin |4 aut | |
| 700 | 1 | |a Brinkley, Emma |e verfasserin |4 aut | |
| 700 | 1 | |a Petruski-Ivleva, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Hawaldar, Kalyani |e verfasserin |4 aut | |
| 700 | 1 | |a Toovey, Stephen |e verfasserin |4 aut | |
| 700 | 1 | |a Morris, Jonathan |e verfasserin |4 aut | |
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