Beta-Blockers and Abdominal Aortic Aneurysm Growth : A Systematic Review and Meta-Analysis
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Aortic aneurysms are worrisome because of their predisposition to dissection and rupture. Beta-blockers are considered first-line therapy for aortic aneurysms. The following meta-analysis assesses if beta-blockers diminish aortic aneurysm growth.
METHODS: A literature search was performed to collect information on clinical trials that have assessed aortic aneurysm growth between beta-blockers and placebo. The primary endpoint was aortic aneurysm growth rate per year. A forest plot with a random-effects model was used for analysis.
RESULTS: Eight clinical trials were included in the analysis. Beta-blockers showed a statistically non-significant effect on aortic aneurysm growth (standard mean difference -0.44; 95% CI [-0.44, 0.00]).
CONCLUSION: Beta-blockers do not significantly influence aortic aneurysm growth. Further studies are required to find a suitable medical therapy to reduce growth rates.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Current cardiology reviews - 17(2021), 4 vom: 04., Seite e230421187502 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Siordia, Juan A [VerfasserIn] |
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| Links: |
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| Themen: |
Adrenergic beta-Antagonists |
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| Anmerkungen: |
Date Completed 05.10.2021 Date Revised 21.07.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1573403X16999201102213619 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317118781 |
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| 245 | 1 | 0 | |a Beta-Blockers and Abdominal Aortic Aneurysm Growth |b A Systematic Review and Meta-Analysis |
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| 500 | |a Date Completed 05.10.2021 | ||
| 500 | |a Date Revised 21.07.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Aortic aneurysms are worrisome because of their predisposition to dissection and rupture. Beta-blockers are considered first-line therapy for aortic aneurysms. The following meta-analysis assesses if beta-blockers diminish aortic aneurysm growth | ||
| 520 | |a METHODS: A literature search was performed to collect information on clinical trials that have assessed aortic aneurysm growth between beta-blockers and placebo. The primary endpoint was aortic aneurysm growth rate per year. A forest plot with a random-effects model was used for analysis | ||
| 520 | |a RESULTS: Eight clinical trials were included in the analysis. Beta-blockers showed a statistically non-significant effect on aortic aneurysm growth (standard mean difference -0.44; 95% CI [-0.44, 0.00]) | ||
| 520 | |a CONCLUSION: Beta-blockers do not significantly influence aortic aneurysm growth. Further studies are required to find a suitable medical therapy to reduce growth rates | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Systematic Review | |
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| 650 | 4 | |a aortic aneurysm | |
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| 650 | 4 | |a meta-analysis. | |
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