Estimated cut-off values for pemphigus severity classification according to pemphigus disease area index (PDAI), autoimmune bullous skin disorder intensity score (ABSIS), and anti-desmoglein 1 autoantibodies
BACKGROUND: Pemphigus is a potentially fatal disease if left untreated. Valid scoring systems and defined cut-off values for classification of patients would help with better management through specified pharmaceutical and non-pharmaceutical treatments.
METHODS: In this study, pemphigus patients who were receiving immunosuppressive treatments and had recent disease relapse were recruited for examination of pemphigus disease area index(PDAI), autoimmune bullous skin disorder intensity score (ABSIS), physician global assessment (PGA), autoimmune bullous disease quality of life (ABQoL), anti-desmoglein 1 (anti-Dsg1), and anti-Dsg3 autoantibody titers from December-2017 to February-2018. Cut-off values were estimated using model-based clustering classification and the 25th and 75th percentiles approach, performed separately for the exclusive cutaneous, exclusive mucosal, and mucocutaneous groups.
RESULTS: In the 109 included patients, the 25th and 75th percentiles cut-offs were 6.2 and 27 for PDAI score, and 4 and 29.5 for ABSIS score. The model-based analysis resulted in two groups (cut-point:15) for PDAI score, and three groups (cut-points:6.4 and 31.5) for ABSIS score. The groups were significantly different for the PDAI, ABSIS, PGA, and ABQoL values. Based on anti-Dsg1 autoantibody values, the model-based analysis cut-point was 128 and the 25th and 75th percentiles cut-offs were 98 and 182. Anti-Dsg3 autoantibody values did not differentiate between pemphigus severity classes.
CONCLUSIONS: Estimated cut-off values based on the anti-Dsg1 level, PDAI, and ABSIS scoring systems could be used to classify patients into different severity grades for better management and prognosis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
|---|---|
| Enthalten in: |
BMC dermatology - 20(2020), 1 vom: 31. Okt., Seite 13 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mohebi, Farnam [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
ABSIS |
|---|
| Anmerkungen: |
Date Completed 25.11.2020 Date Revised 30.03.2024 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1186/s12895-020-00105-y |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM316977497 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM316977497 | ||
| 003 | DE-627 | ||
| 005 | 20240330233337.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s12895-020-00105-y |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1356.xml |
| 035 | |a (DE-627)NLM316977497 | ||
| 035 | |a (NLM)33129291 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mohebi, Farnam |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Estimated cut-off values for pemphigus severity classification according to pemphigus disease area index (PDAI), autoimmune bullous skin disorder intensity score (ABSIS), and anti-desmoglein 1 autoantibodies |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.11.2020 | ||
| 500 | |a Date Revised 30.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Pemphigus is a potentially fatal disease if left untreated. Valid scoring systems and defined cut-off values for classification of patients would help with better management through specified pharmaceutical and non-pharmaceutical treatments | ||
| 520 | |a METHODS: In this study, pemphigus patients who were receiving immunosuppressive treatments and had recent disease relapse were recruited for examination of pemphigus disease area index(PDAI), autoimmune bullous skin disorder intensity score (ABSIS), physician global assessment (PGA), autoimmune bullous disease quality of life (ABQoL), anti-desmoglein 1 (anti-Dsg1), and anti-Dsg3 autoantibody titers from December-2017 to February-2018. Cut-off values were estimated using model-based clustering classification and the 25th and 75th percentiles approach, performed separately for the exclusive cutaneous, exclusive mucosal, and mucocutaneous groups | ||
| 520 | |a RESULTS: In the 109 included patients, the 25th and 75th percentiles cut-offs were 6.2 and 27 for PDAI score, and 4 and 29.5 for ABSIS score. The model-based analysis resulted in two groups (cut-point:15) for PDAI score, and three groups (cut-points:6.4 and 31.5) for ABSIS score. The groups were significantly different for the PDAI, ABSIS, PGA, and ABQoL values. Based on anti-Dsg1 autoantibody values, the model-based analysis cut-point was 128 and the 25th and 75th percentiles cut-offs were 98 and 182. Anti-Dsg3 autoantibody values did not differentiate between pemphigus severity classes | ||
| 520 | |a CONCLUSIONS: Estimated cut-off values based on the anti-Dsg1 level, PDAI, and ABSIS scoring systems could be used to classify patients into different severity grades for better management and prognosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a ABSIS | |
| 650 | 4 | |a Anti-desmoglein | |
| 650 | 4 | |a Autoimmune bullous skin disorder intensity score | |
| 650 | 4 | |a PDAI | |
| 650 | 4 | |a Pemphigus | |
| 650 | 4 | |a Pemphigus disease area index | |
| 650 | 7 | |a Autoantibodies |2 NLM | |
| 650 | 7 | |a Desmoglein 1 |2 NLM | |
| 700 | 1 | |a Tavakolpour, Soheil |e verfasserin |4 aut | |
| 700 | 1 | |a Teimourpour, Amir |e verfasserin |4 aut | |
| 700 | 1 | |a Toosi, Roja |e verfasserin |4 aut | |
| 700 | 1 | |a Mahmoudi, Hamidreza |e verfasserin |4 aut | |
| 700 | 1 | |a Balighi, Kamran |e verfasserin |4 aut | |
| 700 | 1 | |a Ghandi, Narges |e verfasserin |4 aut | |
| 700 | 1 | |a Ghiasi, Maryam |e verfasserin |4 aut | |
| 700 | 1 | |a Nourmohammadpour, Pedram |e verfasserin |4 aut | |
| 700 | 1 | |a Lajevardi, Vahideh |e verfasserin |4 aut | |
| 700 | 1 | |a Abedini, Robabeh |e verfasserin |4 aut | |
| 700 | 1 | |a Azizpour, Armaghan |e verfasserin |4 aut | |
| 700 | 1 | |a Nasimi, Maryam |e verfasserin |4 aut | |
| 700 | 1 | |a Daneshpazhooh, Maryam |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t BMC dermatology |d 2001 |g 20(2020), 1 vom: 31. Okt., Seite 13 |w (DE-627)NLM113478003 |x 1471-5945 |7 nnns |
| 773 | 1 | 8 | |g volume:20 |g year:2020 |g number:1 |g day:31 |g month:10 |g pages:13 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/s12895-020-00105-y |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 20 |j 2020 |e 1 |b 31 |c 10 |h 13 | ||