Individual and Combined Assessment of Ser680Asn FSH Receptor and FSHβ-211 G>T Gene Polymorphisms in Ovarian Response in IVF/ICSI Program
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Molecular biology tools, such as the detection of Single Nucleotide Polymorphisms (SNPs), have been considered to assist in the management of ovarian stimulation protocols.
PURPOSE: The aim of this study was to evaluate the impact of two polymorphisms, the Asn680Ser polymorphism of the FSHR gene, and the FSH β subunit (FSHβ) gene polymorphism -211 G>T, in a Greek population of women undergoing IVF/ICSI program in our center. In addition, a control group of fertile women was studied to verify whether there are differences in the genotype distribution between fertile and infertile population for both polymorphisms, as the FSHβ gene polymorphism -211 G>T is studied for the first time in the Greek population.
RESULTS: The FSH β-211 G>T polymorphism, studied for the first time in the infertile Greek population, appears to be quite rare. When studying the two polymorphisms separately, statistically significant differences were obtained that concerned the LH levels.
DISCUSSION: According to the combination analysis of the two polymorphisms by the number of alleles, women with 2-3 polymorphic alleles needed more days of stimulation, but there were no differences in pregnancy rates.
CONCLUSION: This molecular genetic study helps to elucidate whether the polygenic combination of the Asn680Ser and FSH β subunit -211 G>T gene polymorphisms is of additive value in the prediction of ovarian response to exogenous gonadotropins.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|---|
| Enthalten in: |
Current pharmaceutical biotechnology - 22(2021), 14 vom: 06. Okt., Seite 1857-1865 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Anagnostou, Elli [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
9002-68-0 |
|---|
| Anmerkungen: |
Date Completed 11.10.2021 Date Revised 11.10.2021 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.2174/1389201021666201029153518 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM316899461 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM316899461 | ||
| 003 | DE-627 | ||
| 005 | 20231225162100.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/1389201021666201029153518 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1056.xml |
| 035 | |a (DE-627)NLM316899461 | ||
| 035 | |a (NLM)33121406 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Anagnostou, Elli |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Individual and Combined Assessment of Ser680Asn FSH Receptor and FSHβ-211 G>T Gene Polymorphisms in Ovarian Response in IVF/ICSI Program |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.10.2021 | ||
| 500 | |a Date Revised 11.10.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Molecular biology tools, such as the detection of Single Nucleotide Polymorphisms (SNPs), have been considered to assist in the management of ovarian stimulation protocols | ||
| 520 | |a PURPOSE: The aim of this study was to evaluate the impact of two polymorphisms, the Asn680Ser polymorphism of the FSHR gene, and the FSH β subunit (FSHβ) gene polymorphism -211 G>T, in a Greek population of women undergoing IVF/ICSI program in our center. In addition, a control group of fertile women was studied to verify whether there are differences in the genotype distribution between fertile and infertile population for both polymorphisms, as the FSHβ gene polymorphism -211 G>T is studied for the first time in the Greek population | ||
| 520 | |a RESULTS: The FSH β-211 G>T polymorphism, studied for the first time in the infertile Greek population, appears to be quite rare. When studying the two polymorphisms separately, statistically significant differences were obtained that concerned the LH levels | ||
| 520 | |a DISCUSSION: According to the combination analysis of the two polymorphisms by the number of alleles, women with 2-3 polymorphic alleles needed more days of stimulation, but there were no differences in pregnancy rates | ||
| 520 | |a CONCLUSION: This molecular genetic study helps to elucidate whether the polygenic combination of the Asn680Ser and FSH β subunit -211 G>T gene polymorphisms is of additive value in the prediction of ovarian response to exogenous gonadotropins | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a FSHR | |
| 650 | 4 | |a FSHβ | |
| 650 | 4 | |a ICSI. | |
| 650 | 4 | |a IVF | |
| 650 | 4 | |a SNP | |
| 650 | 4 | |a Ser680Asn | |
| 650 | 4 | |a gene polymorphism | |
| 650 | 7 | |a Follicle Stimulating Hormone, beta Subunit |2 NLM | |
| 650 | 7 | |a Receptors, FSH |2 NLM | |
| 650 | 7 | |a Follicle Stimulating Hormone |2 NLM | |
| 650 | 7 | |a 9002-68-0 |2 NLM | |
| 700 | 1 | |a Kafkoutsou, Alexia |e verfasserin |4 aut | |
| 700 | 1 | |a Mavrogianni, Despina |e verfasserin |4 aut | |
| 700 | 1 | |a Domali, Ekaterini |e verfasserin |4 aut | |
| 700 | 1 | |a Dimitroulia, Evangelia |e verfasserin |4 aut | |
| 700 | 1 | |a Mathiopoulos, Dimitris |e verfasserin |4 aut | |
| 700 | 1 | |a Drakakis, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Loutradis, Dimitris |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current pharmaceutical biotechnology |d 2000 |g 22(2021), 14 vom: 06. Okt., Seite 1857-1865 |w (DE-627)NLM11369072X |x 1873-4316 |7 nnns |
| 773 | 1 | 8 | |g volume:22 |g year:2021 |g number:14 |g day:06 |g month:10 |g pages:1857-1865 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/1389201021666201029153518 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 22 |j 2021 |e 14 |b 06 |c 10 |h 1857-1865 | ||