B Cells in the Gastrointestinal Tumor Microenvironment with a Focus on Pancreatic Cancer : Opportunities for Precision Medicine?
We review state-of-the-art in translational and clinical studies focusing on the tumor microenvironment (TME) with a focus on tumor-infiltrating B cells (TIBs). The TME is a dynamic matrix of mutations, immune-regulatory networks, and distinct cell-to-cell interactions which collectively impact on disease progress. We discuss relevant findings concerning B cells in pancreatic cancer, the concepts of "bystander" B cells, the role of antigen-specific B cells contributing to augmenting anticancer-directed immune responses, the role of B cells as prognostic markers for response to checkpoint inhibitors (ICBs), and the potential use in adoptive cell tumor-infiltrating lymphocyte (TIL) products.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1273 |
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| Enthalten in: |
Advances in experimental medicine and biology - 1273(2020) vom: 29., Seite 175-195 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ligeiro, Dário [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.01.2021 Date Revised 13.01.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/978-3-030-49270-0_10 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316884251 |
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| 520 | |a We review state-of-the-art in translational and clinical studies focusing on the tumor microenvironment (TME) with a focus on tumor-infiltrating B cells (TIBs). The TME is a dynamic matrix of mutations, immune-regulatory networks, and distinct cell-to-cell interactions which collectively impact on disease progress. We discuss relevant findings concerning B cells in pancreatic cancer, the concepts of "bystander" B cells, the role of antigen-specific B cells contributing to augmenting anticancer-directed immune responses, the role of B cells as prognostic markers for response to checkpoint inhibitors (ICBs), and the potential use in adoptive cell tumor-infiltrating lymphocyte (TIL) products | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Adjuvant therapy | |
| 650 | 4 | |a Antibody | |
| 650 | 4 | |a B cells | |
| 650 | 4 | |a Breg | |
| 650 | 4 | |a CDR3 | |
| 650 | 4 | |a Chemotherapy | |
| 650 | 4 | |a Complement | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a ICB | |
| 650 | 4 | |a Immune checkpoint inhibition | |
| 650 | 4 | |a Immune responses | |
| 650 | 4 | |a Immunosuppression | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Pancreatic cancer | |
| 650 | 4 | |a Prognostic markers | |
| 650 | 4 | |a RNA profiling | |
| 650 | 4 | |a TIB | |
| 650 | 4 | |a TIL | |
| 650 | 4 | |a Therapy | |
| 700 | 1 | |a Rao, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Maia, Andreia |e verfasserin |4 aut | |
| 700 | 1 | |a Castillo, Mireia |e verfasserin |4 aut | |
| 700 | 1 | |a Beltran, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Maeurer, Markus |e verfasserin |4 aut | |
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