Parallel Social Information Processing Circuits Are Differentially Impacted in Autism
Copyright © 2020 Elsevier Inc. All rights reserved..
Parallel processing circuits are thought to dramatically expand the network capabilities of the nervous system. Magnocellular and parvocellular oxytocin neurons have been proposed to subserve two parallel streams of social information processing, which allow a single molecule to encode a diverse array of ethologically distinct behaviors. Here we provide the first comprehensive characterization of magnocellular and parvocellular oxytocin neurons in male mice, validated across anatomical, projection target, electrophysiological, and transcriptional criteria. We next use novel multiple feature selection tools in Fmr1-KO mice to provide direct evidence that normal functioning of the parvocellular but not magnocellular oxytocin pathway is required for autism-relevant social reward behavior. Finally, we demonstrate that autism risk genes are enriched in parvocellular compared with magnocellular oxytocin neurons. Taken together, these results provide the first evidence that oxytocin-pathway-specific pathogenic mechanisms account for social impairments across a broad range of autism etiologies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:108 |
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| Enthalten in: |
Neuron - 108(2020), 4 vom: 25. Nov., Seite 659-675.e6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lewis, Eastman M [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 22.01.2021 Date Revised 19.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neuron.2020.10.002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316819573 |
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| 520 | |a Parallel processing circuits are thought to dramatically expand the network capabilities of the nervous system. Magnocellular and parvocellular oxytocin neurons have been proposed to subserve two parallel streams of social information processing, which allow a single molecule to encode a diverse array of ethologically distinct behaviors. Here we provide the first comprehensive characterization of magnocellular and parvocellular oxytocin neurons in male mice, validated across anatomical, projection target, electrophysiological, and transcriptional criteria. We next use novel multiple feature selection tools in Fmr1-KO mice to provide direct evidence that normal functioning of the parvocellular but not magnocellular oxytocin pathway is required for autism-relevant social reward behavior. Finally, we demonstrate that autism risk genes are enriched in parvocellular compared with magnocellular oxytocin neurons. Taken together, these results provide the first evidence that oxytocin-pathway-specific pathogenic mechanisms account for social impairments across a broad range of autism etiologies | ||
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| 700 | 1 | |a Nardou, Romain |e verfasserin |4 aut | |
| 700 | 1 | |a Grossman, Cooper D |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Bangamwabo, Bidii |e verfasserin |4 aut | |
| 700 | 1 | |a Ndiaye, Ndeye |e verfasserin |4 aut | |
| 700 | 1 | |a Giovinazzo, Daniel |e verfasserin |4 aut | |
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| 700 | 1 | |a Dölen, Gül |e verfasserin |4 aut | |
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