Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2
Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2 infection through trained or adaptive immune responses. Here, we tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated that none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post vaccination. We conclude that if such vaccines have any role in COVID-19 immunity, this role is not antibody-mediated.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
PloS one - 15(2020), 10 vom: 28., Seite e0241471 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kandeil, Ahmed [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Neutralizing |
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| Anmerkungen: |
Date Completed 06.11.2020 Date Revised 18.12.2020 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.1371/journal.pone.0241471 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316815438 |
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| 245 | 1 | 0 | |a Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2 |
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| 520 | |a Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2 infection through trained or adaptive immune responses. Here, we tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated that none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post vaccination. We conclude that if such vaccines have any role in COVID-19 immunity, this role is not antibody-mediated | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 7 | |a Antibodies, Neutralizing |2 NLM | |
| 650 | 7 | |a Antibodies, Viral |2 NLM | |
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| 650 | 7 | |a Vaccines |2 NLM | |
| 650 | 7 | |a Vaccines, Inactivated |2 NLM | |
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| 700 | 1 | |a Gomaa, Mokhtar R |e verfasserin |4 aut | |
| 700 | 1 | |a El Taweel, Ahmed |e verfasserin |4 aut | |
| 700 | 1 | |a Mostafa, Ahmed |e verfasserin |4 aut | |
| 700 | 1 | |a Shehata, Mahmoud |e verfasserin |4 aut | |
| 700 | 1 | |a Kayed, Ahmed E |e verfasserin |4 aut | |
| 700 | 1 | |a Kutkat, Omnia |e verfasserin |4 aut | |
| 700 | 1 | |a Moatasim, Yassmin |e verfasserin |4 aut | |
| 700 | 1 | |a Mahmoud, Sara H |e verfasserin |4 aut | |
| 700 | 1 | |a Kamel, Mina Nabil |e verfasserin |4 aut | |
| 700 | 1 | |a Shama, Noura M Abo |e verfasserin |4 aut | |
| 700 | 1 | |a El Sayes, Mohamed |e verfasserin |4 aut | |
| 700 | 1 | |a El-Shesheny, Rabeh |e verfasserin |4 aut | |
| 700 | 1 | |a Yassien, Mahmoud A |e verfasserin |4 aut | |
| 700 | 1 | |a Webby, Richard J |e verfasserin |4 aut | |
| 700 | 1 | |a Kayali, Ghazi |e verfasserin |4 aut | |
| 700 | 1 | |a Ali, Mohamed A |e verfasserin |4 aut | |
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