Bacterial Communities Associated With Abnormal Nugent Score in Postmenopausal Versus Premenopausal Women
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com..
The Nugent score is the reference standard for bacterial vaginosis (BV) diagnosis but has not been validated in postmenopausal women. We compared relative abundances from 16S ribosomal RNA gene sequencing of vaginal microbiota with Nugent score in cohorts of premenopausal (n = 220) and postmenopausal (n = 144) women. In premenopausal women, 33 taxa were significantly correlated with Nugent score, including the classic BV-associated taxa Gardnerella, Atopobium, Sneathia, Megasphaera, and Prevotella. In postmenopausal women, 11 taxa were significantly associated with Nugent score, including Prevotella but no other BV-associated genera. High Nugent scores should not be used to infer BV in postmenopausal women.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:223 |
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Enthalten in: |
The Journal of infectious diseases - 223(2021), 12 vom: 15. Juni, Seite 2048-2052 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Mitchell, Caroline M [VerfasserIn] |
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Links: |
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Themen: |
Bacterial vaginosis |
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Anmerkungen: |
Date Completed 14.02.2022 Date Revised 11.02.2023 published: Print Citation Status MEDLINE |
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doi: |
10.1093/infdis/jiaa675 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM316762849 |
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520 | |a © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com. | ||
520 | |a The Nugent score is the reference standard for bacterial vaginosis (BV) diagnosis but has not been validated in postmenopausal women. We compared relative abundances from 16S ribosomal RNA gene sequencing of vaginal microbiota with Nugent score in cohorts of premenopausal (n = 220) and postmenopausal (n = 144) women. In premenopausal women, 33 taxa were significantly correlated with Nugent score, including the classic BV-associated taxa Gardnerella, Atopobium, Sneathia, Megasphaera, and Prevotella. In postmenopausal women, 11 taxa were significantly associated with Nugent score, including Prevotella but no other BV-associated genera. High Nugent scores should not be used to infer BV in postmenopausal women | ||
650 | 4 | |a Journal Article | |
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700 | 1 | |a Ma, Nanxun |e verfasserin |4 aut | |
700 | 1 | |a Reed, Susan D |e verfasserin |4 aut | |
700 | 1 | |a Wu, Michael C |e verfasserin |4 aut | |
700 | 1 | |a Hoffman, Noah G |e verfasserin |4 aut | |
700 | 1 | |a Valint, Daniel J |e verfasserin |4 aut | |
700 | 1 | |a Proll, Sean |e verfasserin |4 aut | |
700 | 1 | |a Fiedler, Tina L |e verfasserin |4 aut | |
700 | 1 | |a Agnew, Kathy J |e verfasserin |4 aut | |
700 | 1 | |a Guthrie, Katherine A |e verfasserin |4 aut | |
700 | 1 | |a Fredricks, David N |e verfasserin |4 aut | |
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