The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo
Copyright © 2020 Chen, Yang, Shi, Zhang, Song and Huang..
Mammalian ovaries consist of follicles as basic functional units. Each follicle comprised an innermost oocyte and several surrounding flattened granulosa cells. Unlike males, according to the initial size of the primordial follicle pool and the rate of its activation and depletion, a female's reproductive life has been determined early in life. Primordial follicles, once activated, will get into an irreversible process of development. Most follicles undergo atretic degeneration, and only a few of them could mature and ovulate. Although there are a lot of researches contributing to exploring the activation of primordial follicles, little is known about its underlying mechanisms. Thus, in this review, we collected the latest papers and summarized the signaling pathways as well as some factors involved in the activation of primordial follicles, hoping to lead to a more profound understanding of the cellular and molecular mechanisms of primordial follicle activation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Frontiers in cell and developmental biology - 8(2020) vom: 14., Seite 575706 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Yao [VerfasserIn] |
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| Links: |
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| Themen: |
Activation |
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| Anmerkungen: |
Date Revised 28.10.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fcell.2020.575706 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM31671299X |
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| 520 | |a Copyright © 2020 Chen, Yang, Shi, Zhang, Song and Huang. | ||
| 520 | |a Mammalian ovaries consist of follicles as basic functional units. Each follicle comprised an innermost oocyte and several surrounding flattened granulosa cells. Unlike males, according to the initial size of the primordial follicle pool and the rate of its activation and depletion, a female's reproductive life has been determined early in life. Primordial follicles, once activated, will get into an irreversible process of development. Most follicles undergo atretic degeneration, and only a few of them could mature and ovulate. Although there are a lot of researches contributing to exploring the activation of primordial follicles, little is known about its underlying mechanisms. Thus, in this review, we collected the latest papers and summarized the signaling pathways as well as some factors involved in the activation of primordial follicles, hoping to lead to a more profound understanding of the cellular and molecular mechanisms of primordial follicle activation | ||
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| 650 | 4 | |a signaling pathways | |
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| 700 | 1 | |a Shi, Xu |e verfasserin |4 aut | |
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| 700 | 1 | |a Song, Ge |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Donghui |e verfasserin |4 aut | |
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