Decreased Resting-State Interhemispheric Functional Connectivity in Medication-Free Obsessive-Compulsive Disorder
Copyright © 2020 Jia, Ou, Chen, Li, Lv, Yang, Zhong, Sun, Wang, Zhang, Guo, Sun, Wang, Wang, Wang and Guo..
OBJECTIVE: Decreased homotopic connectivity of brain networks such as the cortico-striato-thalamo-cortical (CSTC) circuits may contribute to the pathophysiology of obsessive-compulsive disorder (OCD). However, little is known about interhemispheric functional connectivity (FC) at rest in OCD. In this study, the voxel-mirrored homotopic connectivity (VMHC) method was applied to explore interhemispheric coordination at rest in OCD.
METHODS: Forty medication-free patients with OCD and 38 sex-, age-, and education level-matched healthy controls (HCs) underwent a resting-state functional magnetic resonance imaging. The VMHC and support vector machine (SVM) methods were used to analyze the data.
RESULTS: Patients with OCD had remarkably decreased VMHC values in the orbitofrontal cortex, thalamus, middle occipital gyrus, and precentral and postcentral gyri compared with HCs. A combination of the VMHC values in the thalamus and postcentral gyrus could optimally distinguish patients with OCD from HCs.
CONCLUSIONS: Our findings highlight the contribution of decreased interhemispheric FC within and outside the CSTC circuits in OCD and provide evidence to the pathophysiology of OCD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Frontiers in psychiatry - 11(2020) vom: 16., Seite 559729 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jia, Cuicui [VerfasserIn] |
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| Links: |
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| Themen: |
Functional magnetic resonance imaging |
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| Anmerkungen: |
Date Revised 29.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fpsyt.2020.559729 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316699039 |
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| 520 | |a Copyright © 2020 Jia, Ou, Chen, Li, Lv, Yang, Zhong, Sun, Wang, Zhang, Guo, Sun, Wang, Wang, Wang and Guo. | ||
| 520 | |a OBJECTIVE: Decreased homotopic connectivity of brain networks such as the cortico-striato-thalamo-cortical (CSTC) circuits may contribute to the pathophysiology of obsessive-compulsive disorder (OCD). However, little is known about interhemispheric functional connectivity (FC) at rest in OCD. In this study, the voxel-mirrored homotopic connectivity (VMHC) method was applied to explore interhemispheric coordination at rest in OCD | ||
| 520 | |a METHODS: Forty medication-free patients with OCD and 38 sex-, age-, and education level-matched healthy controls (HCs) underwent a resting-state functional magnetic resonance imaging. The VMHC and support vector machine (SVM) methods were used to analyze the data | ||
| 520 | |a RESULTS: Patients with OCD had remarkably decreased VMHC values in the orbitofrontal cortex, thalamus, middle occipital gyrus, and precentral and postcentral gyri compared with HCs. A combination of the VMHC values in the thalamus and postcentral gyrus could optimally distinguish patients with OCD from HCs | ||
| 520 | |a CONCLUSIONS: Our findings highlight the contribution of decreased interhemispheric FC within and outside the CSTC circuits in OCD and provide evidence to the pathophysiology of OCD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a functional magnetic resonance imaging | |
| 650 | 4 | |a obsessive-compulsive disorder | |
| 650 | 4 | |a resting-state | |
| 650 | 4 | |a support vector machine | |
| 650 | 4 | |a voxel-mirrored homotopic connectivity | |
| 700 | 1 | |a Ou, Yangpan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yunhui |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Ru |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Zhaoxi |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yuhua |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Guangfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Zhenghai |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yefu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaoping |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Wenbin |e verfasserin |4 aut | |
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