Intracranial chordoid glioma : A clinical, radiological and pathological study of 14 cases
Copyright © 2020. Published by Elsevier Ltd..
BACKGROUND: Chordoid gliomas (CGs) are rare neuroepithelial tumors, which commonly arise from the anterior part of the third ventricle. Most studies on CGs included only one or two cases. To better understand the disease, we report 14 patients with pathologically confirmed CGs.
METHOD: The clinical characteristics, including radiological and histological examination, operative records, and prognoses were analyzed and reviewed.
RESULT: The case series included six male and eight female patients with an average age of 44.4 years. The most common preoperative symptom was headache (64.3%) and visual deterioration (57.1%). Radiological results showed that the third ventricle (12/14) was the most common site of the brain involved, and the lesions presented with solid (n = 9, 64.3%) or cystic-solid (n = 5, 35.7%) appearance. All patients were misdiagnosed as non-CG tumors. The operation approach was mainly determined by tumor location, thus trans-callosal approach (9/14) and trans-laminar terminalis approach were commonly used. Gross total resection (GTR) was achieved in all cases and none of them received any adjuvant therapy postoperatively. The most frequent postoperative complications were diabetes insipidus, electrolyte disturbance, hypopituitarism, cognitive dysfunction, and obstructive hydrocephalus. During an average follow-up period of 40.1 months, 2 cases (14.3%) were died of refractory hypopituitarism and pulmonary embolism, respectively. The preoperative symptoms and postoperative complications were all significantly improved in other 12 patients, and MRI showed no tumor recurrence.
CONCLUSION: According to our experience, we recommend GTR as the primary goal, which is associated with improved rates of tumor control and without increasing rates of postoperative complications.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:80 |
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| Enthalten in: |
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 80(2020) vom: 24. Okt., Seite 267-273 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Guo-Bin [VerfasserIn] |
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| Links: |
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| Themen: |
Chordoid glioma |
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| Anmerkungen: |
Date Completed 15.02.2021 Date Revised 15.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jocn.2020.09.019 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316681903 |
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| 500 | |a Date Revised 15.02.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020. Published by Elsevier Ltd. | ||
| 520 | |a BACKGROUND: Chordoid gliomas (CGs) are rare neuroepithelial tumors, which commonly arise from the anterior part of the third ventricle. Most studies on CGs included only one or two cases. To better understand the disease, we report 14 patients with pathologically confirmed CGs | ||
| 520 | |a METHOD: The clinical characteristics, including radiological and histological examination, operative records, and prognoses were analyzed and reviewed | ||
| 520 | |a RESULT: The case series included six male and eight female patients with an average age of 44.4 years. The most common preoperative symptom was headache (64.3%) and visual deterioration (57.1%). Radiological results showed that the third ventricle (12/14) was the most common site of the brain involved, and the lesions presented with solid (n = 9, 64.3%) or cystic-solid (n = 5, 35.7%) appearance. All patients were misdiagnosed as non-CG tumors. The operation approach was mainly determined by tumor location, thus trans-callosal approach (9/14) and trans-laminar terminalis approach were commonly used. Gross total resection (GTR) was achieved in all cases and none of them received any adjuvant therapy postoperatively. The most frequent postoperative complications were diabetes insipidus, electrolyte disturbance, hypopituitarism, cognitive dysfunction, and obstructive hydrocephalus. During an average follow-up period of 40.1 months, 2 cases (14.3%) were died of refractory hypopituitarism and pulmonary embolism, respectively. The preoperative symptoms and postoperative complications were all significantly improved in other 12 patients, and MRI showed no tumor recurrence | ||
| 520 | |a CONCLUSION: According to our experience, we recommend GTR as the primary goal, which is associated with improved rates of tumor control and without increasing rates of postoperative complications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chordoid glioma | |
| 650 | 4 | |a Clinical features | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Surgical resection | |
| 650 | 4 | |a Third ventricle | |
| 700 | 1 | |a Huang, Hua-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Hao-Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiao-Kang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yong-Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Song |e verfasserin |4 aut | |
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