The clinical significance of small sharp spikes : A retrospective study of 909 patients in epilepsy monitoring unit
Copyright © 2020 Elsevier B.V. All rights reserved..
OBJECTIVES: To determine the incidence and clinical significance of small sharp spikes (SSS) in the patient population of the adult Epilepsy Monitoring Unit (EMU).
METHODS: This is a retrospective study of EEG data and medical records from consecutive patients who underwent video-EEG recording in the adult EMU from March 2013 to February 2019. SSS, interictal epileptiform discharges (IEDs), and ictal patterns were identified.
RESULTS: Of the 909 patients reviewed, SSS were observed in110 (12.1 %) patients. Epilepsy was present in 101 of the 110 (91.8 %) patients with SSS and in 441 of the 799 (55.2 %) patients without SSS. The incidence of epilepsy was significantly higher in patients with SSS than in those without SSS (OR = 9.1, 95 % CI: 4.5-18.3, P < 0.01). The sensitivity of SSS for epilepsy was 18.6 % and the specificity was 97.5 %. The incidence of SSS was strongly correlated with the frequency of IEDs (OR 1.89; 95 %CI: 1.60-2.24, P < 0.01). When both present, SSS and IEDs were co-lateralized in the same hemisphere.
CONCLUSIONS: There is a statistically significant association between SSS and focal epilepsy. SSS have similar clinical implications to IEDs in the lateralization and localization of temporal lobe seizures. SSS can be an epileptiform EEG pattern for temporal lobe epilepsy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:168 |
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| Enthalten in: |
Epilepsy research - 168(2020) vom: 16. Dez., Seite 106477 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Ziyi [VerfasserIn] |
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| Links: |
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| Themen: |
EEG |
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| Anmerkungen: |
Date Completed 06.10.2021 Date Revised 06.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.eplepsyres.2020.106477 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316651818 |
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| 100 | 1 | |a Chen, Ziyi |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The clinical significance of small sharp spikes |b A retrospective study of 909 patients in epilepsy monitoring unit |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 06.10.2021 | ||
| 500 | |a Date Revised 06.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVES: To determine the incidence and clinical significance of small sharp spikes (SSS) in the patient population of the adult Epilepsy Monitoring Unit (EMU) | ||
| 520 | |a METHODS: This is a retrospective study of EEG data and medical records from consecutive patients who underwent video-EEG recording in the adult EMU from March 2013 to February 2019. SSS, interictal epileptiform discharges (IEDs), and ictal patterns were identified | ||
| 520 | |a RESULTS: Of the 909 patients reviewed, SSS were observed in110 (12.1 %) patients. Epilepsy was present in 101 of the 110 (91.8 %) patients with SSS and in 441 of the 799 (55.2 %) patients without SSS. The incidence of epilepsy was significantly higher in patients with SSS than in those without SSS (OR = 9.1, 95 % CI: 4.5-18.3, P < 0.01). The sensitivity of SSS for epilepsy was 18.6 % and the specificity was 97.5 %. The incidence of SSS was strongly correlated with the frequency of IEDs (OR 1.89; 95 %CI: 1.60-2.24, P < 0.01). When both present, SSS and IEDs were co-lateralized in the same hemisphere | ||
| 520 | |a CONCLUSIONS: There is a statistically significant association between SSS and focal epilepsy. SSS have similar clinical implications to IEDs in the lateralization and localization of temporal lobe seizures. SSS can be an epileptiform EEG pattern for temporal lobe epilepsy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a EEG | |
| 650 | 4 | |a Epilepsy | |
| 650 | 4 | |a Ictal epileptic discharges | |
| 650 | 4 | |a Interictal epileptiform discharges | |
| 650 | 4 | |a Small sharp spikes | |
| 700 | 1 | |a Issa, Naoum P |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Shasha |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xi |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Taixin |e verfasserin |4 aut | |
| 700 | 1 | |a Bodnya, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Rose, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Tao, James X |e verfasserin |4 aut | |
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