Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell's transition. Previous studies imply that changes in the cancer stem cells can affect the malignant differentiation of the tumor. We found that the epithelial-to-mesenchymal transition (EMT)-related regulatory pathway is an important target for tumor therapy. In this review, we discuss the transition factor of EMT and 3 specific pathways that affect the EMT of cancer stem cells during tumor development. We conclude that targeting the EMT process of cancer stem cells can be a feasible approach in the treatment of glioma.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Technology in cancer research & treatment - 19(2020) vom: 01. Jan., Seite 1533033820948053 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lu, Yu-Bao [VerfasserIn] |
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| Links: |
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| Themen: |
Antineoplastic Agents |
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| Anmerkungen: |
Date Completed 24.11.2021 Date Revised 24.11.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1177/1533033820948053 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316587249 |
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| 520 | |a Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell's transition. Previous studies imply that changes in the cancer stem cells can affect the malignant differentiation of the tumor. We found that the epithelial-to-mesenchymal transition (EMT)-related regulatory pathway is an important target for tumor therapy. In this review, we discuss the transition factor of EMT and 3 specific pathways that affect the EMT of cancer stem cells during tumor development. We conclude that targeting the EMT process of cancer stem cells can be a feasible approach in the treatment of glioma | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a glioma | |
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| 700 | 1 | |a Chen, Yu-Tong |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Zong-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Jia-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Miao, Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yong-Na |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Shi-Xin |e verfasserin |4 aut | |
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