Biopsy-proven Henoch-Schönlein purpura nephritis : a single center experience
BACKGROUND: Knowledge on normal progress and treatment of Henoch-Schönlein purpura nephritis (HSPN) is limited. This study reviews outcome, clinical, pathological, and therapeutic factors affecting the prognosis of HSPN patients.
METHODS: Forty-nine children with biopsy-confirmed HSPN diagnosed between September 2008 and 2018 were included. Demographics, clinical and laboratory data, treatment, and outcome were recorded at the time of biopsy, 3, 6, 12, and 24 months and at last visit. Clinical outcome was graded according to Meadow's criteria.
RESULTS: The median age at time of biopsy was 10.1 years (IQR:5.7) and female/male ratio 24/25. At presentation, 40.8% of patients had nonnephrotic proteinuria, 18.4% nephrotic syndrome (NS), 4.1% nephritic syndrome (NephrS), and 36.7% NephrS+NS. There were 11 patients with an estimated glomerular filtration rate below 90 ml/min/1.73 m2. Biopsy specimens were classified according to International Study of Kidney Diseases in Children (ISKDC) and Oxford Classification MEST-C scoring systems. Forty-one patients received angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, 37 patients steroids, and 35 patients other immunosuppressive medications. At last visit, 24 patients had stage 1 chronic kidney disease (CKD), three stage 2 CKD, and two had stage 5 CKD. Neither clinical parameters nor ISKDC biopsy grade or treatment modalities effected the final outcome. The Oxford classification showed significantly increased segmental glomerulosclerosis in patients with unfavorable outcome. Favorable outcome was associated with shorter time from kidney involvement to biopsy and start of treatment.
CONCLUSION: A large proportion of patients continued to show signs of CKD at last follow-up while only a small proportion developed stage 5 CKD.
Errataetall: |
CommentIn: Pediatr Nephrol. 2022 Apr;37(4):913-914. - PMID 35006360 |
---|---|
Medienart: |
E-Artikel |
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
---|---|
Enthalten in: |
Pediatric nephrology (Berlin, Germany) - 36(2021), 5 vom: 21. Mai, Seite 1207-1215 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Kurt-Şükür, Eda Didem [VerfasserIn] |
---|
Links: |
---|
Themen: |
Chronic kidney disease |
---|
Anmerkungen: |
Date Completed 14.02.2022 Date Revised 08.05.2022 published: Print-Electronic CommentIn: Pediatr Nephrol. 2022 Apr;37(4):913-914. - PMID 35006360 Citation Status MEDLINE |
---|
doi: |
10.1007/s00467-020-04809-8 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM316583480 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM316583480 | ||
003 | DE-627 | ||
005 | 20231225161413.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00467-020-04809-8 |2 doi | |
028 | 5 | 2 | |a pubmed24n1055.xml |
035 | |a (DE-627)NLM316583480 | ||
035 | |a (NLM)33089378 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Kurt-Şükür, Eda Didem |e verfasserin |4 aut | |
245 | 1 | 0 | |a Biopsy-proven Henoch-Schönlein purpura nephritis |b a single center experience |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 14.02.2022 | ||
500 | |a Date Revised 08.05.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a CommentIn: Pediatr Nephrol. 2022 Apr;37(4):913-914. - PMID 35006360 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a BACKGROUND: Knowledge on normal progress and treatment of Henoch-Schönlein purpura nephritis (HSPN) is limited. This study reviews outcome, clinical, pathological, and therapeutic factors affecting the prognosis of HSPN patients | ||
520 | |a METHODS: Forty-nine children with biopsy-confirmed HSPN diagnosed between September 2008 and 2018 were included. Demographics, clinical and laboratory data, treatment, and outcome were recorded at the time of biopsy, 3, 6, 12, and 24 months and at last visit. Clinical outcome was graded according to Meadow's criteria | ||
520 | |a RESULTS: The median age at time of biopsy was 10.1 years (IQR:5.7) and female/male ratio 24/25. At presentation, 40.8% of patients had nonnephrotic proteinuria, 18.4% nephrotic syndrome (NS), 4.1% nephritic syndrome (NephrS), and 36.7% NephrS+NS. There were 11 patients with an estimated glomerular filtration rate below 90 ml/min/1.73 m2. Biopsy specimens were classified according to International Study of Kidney Diseases in Children (ISKDC) and Oxford Classification MEST-C scoring systems. Forty-one patients received angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, 37 patients steroids, and 35 patients other immunosuppressive medications. At last visit, 24 patients had stage 1 chronic kidney disease (CKD), three stage 2 CKD, and two had stage 5 CKD. Neither clinical parameters nor ISKDC biopsy grade or treatment modalities effected the final outcome. The Oxford classification showed significantly increased segmental glomerulosclerosis in patients with unfavorable outcome. Favorable outcome was associated with shorter time from kidney involvement to biopsy and start of treatment | ||
520 | |a CONCLUSION: A large proportion of patients continued to show signs of CKD at last follow-up while only a small proportion developed stage 5 CKD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Chronic kidney disease | |
650 | 4 | |a HSPN | |
650 | 4 | |a Immunoglobulin A vasculitis | |
650 | 4 | |a Outcome | |
650 | 4 | |a Pediatrics | |
650 | 4 | |a Prognosis | |
650 | 4 | |a Treatment | |
700 | 1 | |a Sekar, Thivya |e verfasserin |4 aut | |
700 | 1 | |a Tullus, Kjell |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Pediatric nephrology (Berlin, Germany) |d 1995 |g 36(2021), 5 vom: 21. Mai, Seite 1207-1215 |w (DE-627)NLM012612111 |x 1432-198X |7 nnns |
773 | 1 | 8 | |g volume:36 |g year:2021 |g number:5 |g day:21 |g month:05 |g pages:1207-1215 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00467-020-04809-8 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 36 |j 2021 |e 5 |b 21 |c 05 |h 1207-1215 |