Co-exposure of serum calcium, selenium and vanadium is nonlinearly associated with increased risk of type 2 diabetes mellitus in a Chinese population
Copyright © 2020 Elsevier Ltd. All rights reserved..
BACKGROUND: Metals play an important role in type 2 diabetes mellitus (T2DM). This study aimed to explore the association of T2DM risk with single metal exposure and multi-metal co-exposure.
METHODS: A case-control study with 223 T2DM patients and 302 controls was conducted. Serum concentrations of 19 metals were determined by inductively coupled plasma mass spectrometry (ICP-MS). Those metals with greater effects were screened out and co-exposure effects of metals were assessed by least absolute shrinkage and selection operator (LASSO) regression.
RESULTS: Serum calcium (Ca), selenium (Se) and vanadium (V) were found with greater effects. Higher levels of Ca and Se were associated with increased T2DM risk (OR = 2.23, 95%CI: 1.38-3.62, Ptrend = 0.002; OR = 3.16, 95%CI: 1.82-5.50, Ptrend < 0.001), but higher V level was associated with decreased T2DM risk (OR = 0.58, 95%CI: 0.34-0.97, Ptrend < 0.001). Serum Ca and V concentrations were nonlinearly associated with T2DM risk (Poverall < 0.001, Pnonliearity < 0.001); however, Se concentration was linearly associated with T2DM risk (Poverall < 0.001, Pnonliearity = 0.389). High co-exposure score of serum Ca, Se and V was associated with increased T2DM risk (OR = 3.50, 95%CI: 2.08-5.89, Ptrend < 0.001) as a non-linear relationship (Poverall < 0.001, Pnonliearity = 0.003).
CONCLUSIONS: This study suggest that higher levels of serum Ca and Se were associated with increased T2DM risk, but higher serum V level was associated with decreased T2DM risk. Moreover, co-exposure of serum Ca, Se and V was nonlinearly associated with T2DM risk, and high co-exposure score was positively associated with T2DM risk.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:263 |
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| Enthalten in: |
Chemosphere - 263(2021) vom: 20. Jan., Seite 128021 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lv, Yingnan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.12.2020 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.chemosphere.2020.128021 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Co-exposure of serum calcium, selenium and vanadium is nonlinearly associated with increased risk of type 2 diabetes mellitus in a Chinese population |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 11.12.2020 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: Metals play an important role in type 2 diabetes mellitus (T2DM). This study aimed to explore the association of T2DM risk with single metal exposure and multi-metal co-exposure | ||
| 520 | |a METHODS: A case-control study with 223 T2DM patients and 302 controls was conducted. Serum concentrations of 19 metals were determined by inductively coupled plasma mass spectrometry (ICP-MS). Those metals with greater effects were screened out and co-exposure effects of metals were assessed by least absolute shrinkage and selection operator (LASSO) regression | ||
| 520 | |a RESULTS: Serum calcium (Ca), selenium (Se) and vanadium (V) were found with greater effects. Higher levels of Ca and Se were associated with increased T2DM risk (OR = 2.23, 95%CI: 1.38-3.62, Ptrend = 0.002; OR = 3.16, 95%CI: 1.82-5.50, Ptrend < 0.001), but higher V level was associated with decreased T2DM risk (OR = 0.58, 95%CI: 0.34-0.97, Ptrend < 0.001). Serum Ca and V concentrations were nonlinearly associated with T2DM risk (Poverall < 0.001, Pnonliearity < 0.001); however, Se concentration was linearly associated with T2DM risk (Poverall < 0.001, Pnonliearity = 0.389). High co-exposure score of serum Ca, Se and V was associated with increased T2DM risk (OR = 3.50, 95%CI: 2.08-5.89, Ptrend < 0.001) as a non-linear relationship (Poverall < 0.001, Pnonliearity = 0.003) | ||
| 520 | |a CONCLUSIONS: This study suggest that higher levels of serum Ca and Se were associated with increased T2DM risk, but higher serum V level was associated with decreased T2DM risk. Moreover, co-exposure of serum Ca, Se and V was nonlinearly associated with T2DM risk, and high co-exposure score was positively associated with T2DM risk | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a LASSO regression | |
| 650 | 4 | |a Metal co-exposure | |
| 650 | 4 | |a Nonlinear relationship | |
| 650 | 4 | |a Restricted cubic splines regression | |
| 650 | 4 | |a Type 2 diabetes mellitus | |
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| 650 | 7 | |a Vanadium |2 NLM | |
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| 650 | 7 | |a Selenium |2 NLM | |
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| 650 | 7 | |a Calcium |2 NLM | |
| 650 | 7 | |a SY7Q814VUP |2 NLM | |
| 700 | 1 | |a Xie, Lianguang |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Chunting |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Rongqing |e verfasserin |4 aut | |
| 700 | 1 | |a Long, Tianzhu |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Haisheng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Lulin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Lulu |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xiaolang |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Xiaoyu |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Sifang |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xiaobo |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Haiying |e verfasserin |4 aut | |
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