Alpha-1-microglobulin : Prognostic value in chronic kidney disease
Copyright © 2020 Elsevier España, S.L.U. All rights reserved..
OBJECTIVES: α1-microglobulin (α1M) is a tubular protein used for detecting acute lesions of proximal tubules. This study evaluated the use of urine α1M excretion as a marker of chronic kidney disease (CKD) progression and life survival.
DESIGN AND METHODS: In all 163 patients were recruited (90 men), mean age 61.6±16.4 years. Urinary α1M was evaluated using an immunonephelometric assay. Patients were divided into 2 groups according to urinary α1M excretion (cut-off value: 32.85mg/24h).
RESULTS: End stage renal disease-free survival was 94.2% at 5 years for patients with lower α1M. For patients in the highest percentile, renal function survival was 72.7% (P=.011). Life survival was 94.4% for patients with α1M in the lower percentiles. For patients in the upper percentile, live survival was 54.2% (P=.001). The Cox regression analysis showed an independent association of CKD progression with high α1M excretion (P=.043).
CONCLUSIONS: α1M urinary excretion was associated with faster CKD progression and higher mortality. Further studies are needed to determine whether the association between α1M urinary excretion and excess mortality risk represents a causal link.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:157 |
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| Enthalten in: |
Medicina clinica - 157(2021), 8 vom: 22. Okt., Seite 368-370 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
Alfa-1-microglobulina: valor pronóstico en la enfermedad renal crónica |
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| Beteiligte Personen: |
Robles, Nicolás R [VerfasserIn] |
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| Links: |
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| Themen: |
Alfa-1-microglobulina |
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| Anmerkungen: |
Date Completed 22.10.2021 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.medcli.2020.06.061 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316388297 |
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| 245 | 1 | 0 | |a Alpha-1-microglobulin |b Prognostic value in chronic kidney disease |
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| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a OBJECTIVES: α1-microglobulin (α1M) is a tubular protein used for detecting acute lesions of proximal tubules. This study evaluated the use of urine α1M excretion as a marker of chronic kidney disease (CKD) progression and life survival | ||
| 520 | |a DESIGN AND METHODS: In all 163 patients were recruited (90 men), mean age 61.6±16.4 years. Urinary α1M was evaluated using an immunonephelometric assay. Patients were divided into 2 groups according to urinary α1M excretion (cut-off value: 32.85mg/24h) | ||
| 520 | |a RESULTS: End stage renal disease-free survival was 94.2% at 5 years for patients with lower α1M. For patients in the highest percentile, renal function survival was 72.7% (P=.011). Life survival was 94.4% for patients with α1M in the lower percentiles. For patients in the upper percentile, live survival was 54.2% (P=.001). The Cox regression analysis showed an independent association of CKD progression with high α1M excretion (P=.043) | ||
| 520 | |a CONCLUSIONS: α1M urinary excretion was associated with faster CKD progression and higher mortality. Further studies are needed to determine whether the association between α1M urinary excretion and excess mortality risk represents a causal link | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alfa-1-microglobulina | |
| 650 | 4 | |a Alpha-1-microglobulin | |
| 650 | 4 | |a Chronic kidney disease | |
| 650 | 4 | |a Enfermedad renal crónica | |
| 650 | 4 | |a Mortalidad | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Pronóstico | |
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| 700 | 1 | |a Valladares, Julian |e verfasserin |4 aut | |
| 700 | 1 | |a Hernandez Gallego, Roman |e verfasserin |4 aut | |
| 700 | 1 | |a Cerezo, Isis |e verfasserin |4 aut | |
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