Low Muscle Mass is Associated with Walking Function in Patients with Acute Ischemic Stroke
Copyright © 2020 Elsevier Inc. All rights reserved..
BACKGROUND: Muscle mass might be a possible predictor for walking function in patients with stroke; however, evidence is limited.
OBJECTIVE: To investigate whether skeletal muscle mass is associated with walking function at discharge during the acute phase.
METHODS: In this observational cohort study, we assessed skeletal muscle mass in patients with acute ischemic stroke using the noninvasive and portable multifrequency bio-impedance device. This device can easily be used in bedridden patients. Appendicular skeletal muscle mass was converted to skeletal muscle index (SMI) standardizing by height squared (kg/m2). The primary outcome was walking function assessed by the modified Rankin Scale score at acute phase hospital discharge. Logistic regression analysis was used to determine the association between skeletal muscle mass and walking function.
RESULTS: Of the 107 patients enrolled, low SMI (SMI: male <7.0 kg/m2, female <5.7 kg/m2) was identified in 29.9% (19.7% in men, 48.6% in women). Logistic regression analysis showed that low SMI [OR: 4.02, 95% confidence interval (CI): 1.38-11.7, p = 0.001] independently associated with walking function at discharge. Further, patients with mild and moderate severity had significant difficulty in walking when they had low SMI (p = 0.039).
CONCLUSIONS: Low skeletal muscle mass at the onset of ischemic stroke is an independent predictor of walking function at discharge during the acute phase. Our findings highlight the importance of detecting skeletal muscle mass in patients with acute ischemic stroke.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 29(2020), 11 vom: 16. Nov., Seite 105259 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abe, Takafumi [VerfasserIn] |
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| Links: |
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| Themen: |
Cerebral infarction |
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| Anmerkungen: |
Date Completed 04.12.2020 Date Revised 14.12.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jstrokecerebrovasdis.2020.105259 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316363537 |
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| 100 | 1 | |a Abe, Takafumi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Low Muscle Mass is Associated with Walking Function in Patients with Acute Ischemic Stroke |
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| 500 | |a Date Revised 14.12.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Muscle mass might be a possible predictor for walking function in patients with stroke; however, evidence is limited | ||
| 520 | |a OBJECTIVE: To investigate whether skeletal muscle mass is associated with walking function at discharge during the acute phase | ||
| 520 | |a METHODS: In this observational cohort study, we assessed skeletal muscle mass in patients with acute ischemic stroke using the noninvasive and portable multifrequency bio-impedance device. This device can easily be used in bedridden patients. Appendicular skeletal muscle mass was converted to skeletal muscle index (SMI) standardizing by height squared (kg/m2). The primary outcome was walking function assessed by the modified Rankin Scale score at acute phase hospital discharge. Logistic regression analysis was used to determine the association between skeletal muscle mass and walking function | ||
| 520 | |a RESULTS: Of the 107 patients enrolled, low SMI (SMI: male <7.0 kg/m2, female <5.7 kg/m2) was identified in 29.9% (19.7% in men, 48.6% in women). Logistic regression analysis showed that low SMI [OR: 4.02, 95% confidence interval (CI): 1.38-11.7, p = 0.001] independently associated with walking function at discharge. Further, patients with mild and moderate severity had significant difficulty in walking when they had low SMI (p = 0.039) | ||
| 520 | |a CONCLUSIONS: Low skeletal muscle mass at the onset of ischemic stroke is an independent predictor of walking function at discharge during the acute phase. Our findings highlight the importance of detecting skeletal muscle mass in patients with acute ischemic stroke | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Cerebral infarction | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Rehabilitation | |
| 650 | 4 | |a Sarcopenia | |
| 650 | 4 | |a Skeletal muscle | |
| 650 | 4 | |a Stroke | |
| 650 | 4 | |a Walking | |
| 700 | 1 | |a Iwata, Kentaro |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshimura, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Shinoda, Taku |e verfasserin |4 aut | |
| 700 | 1 | |a Inagaki, Yuta |e verfasserin |4 aut | |
| 700 | 1 | |a Ohya, Shuhei |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, Kanji |e verfasserin |4 aut | |
| 700 | 1 | |a Oyanagi, Keiichi |e verfasserin |4 aut | |
| 700 | 1 | |a Maekawa, Yukihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Honda, Akihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kohara, Nobuo |e verfasserin |4 aut | |
| 700 | 1 | |a Tsubaki, Atsuhiro |e verfasserin |4 aut | |
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