Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis
PURPOSE: We investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with clinical node-positive disease (cN +).
METHODS: The subjects of this study were 60 patients with cN + , who received NAC followed by breast surgery with axillary lymph node dissection (ALND). We conducted a semi-quantitative assessment of TILs in pretreatment primary tumors and their association with clinicopathological factors and axillary lymph node metastasis.
RESULTS: We observed a higher number of TILs in tumors with negative hormone receptors, positive human epidermal growth factor receptor 2, or high Ki67. TILs were associated with a favorable response to NAC in primary tumors. The rate of axillary pathologic complete response (Ax-pCR) was significantly higher in patients with a high number of TILs than in patients with a low number of TILs (72.0% versus 17.1%, p < 0.001). In multivariable analysis, a high number of TILs was a significant predictor of Ax-pCR as well as of pCR of the primary tumor after NAC. Importantly, all patients with HER2-positive tumors in the high TILs group showed Ax-pCR on ALND.
CONCLUSION: TILs in pretreatment primary breast cancer had the potential to predict therapeutic efficacy of NAC in patients with clinical node-positive disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Surgery today - 51(2021), 4 vom: 14. Apr., Seite 595-604 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yokotani, Tomoyo [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 15.09.2021 Date Revised 15.09.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00595-020-02157-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316221384 |
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| 100 | 1 | |a Yokotani, Tomoyo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 15.09.2021 | ||
| 500 | |a Date Revised 15.09.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: We investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with clinical node-positive disease (cN +) | ||
| 520 | |a METHODS: The subjects of this study were 60 patients with cN + , who received NAC followed by breast surgery with axillary lymph node dissection (ALND). We conducted a semi-quantitative assessment of TILs in pretreatment primary tumors and their association with clinicopathological factors and axillary lymph node metastasis | ||
| 520 | |a RESULTS: We observed a higher number of TILs in tumors with negative hormone receptors, positive human epidermal growth factor receptor 2, or high Ki67. TILs were associated with a favorable response to NAC in primary tumors. The rate of axillary pathologic complete response (Ax-pCR) was significantly higher in patients with a high number of TILs than in patients with a low number of TILs (72.0% versus 17.1%, p < 0.001). In multivariable analysis, a high number of TILs was a significant predictor of Ax-pCR as well as of pCR of the primary tumor after NAC. Importantly, all patients with HER2-positive tumors in the high TILs group showed Ax-pCR on ALND | ||
| 520 | |a CONCLUSION: TILs in pretreatment primary breast cancer had the potential to predict therapeutic efficacy of NAC in patients with clinical node-positive disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Axillary dissection | |
| 650 | 4 | |a Axillary pathological complete response | |
| 650 | 4 | |a Breast cancer | |
| 650 | 4 | |a Neoadjuvant chemotherapy | |
| 650 | 4 | |a Tumor-infiltrating lymphocytes | |
| 650 | 7 | |a Ki-67 Antigen |2 NLM | |
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| 700 | 1 | |a Ikeda, Noaya |e verfasserin |4 aut | |
| 700 | 1 | |a Hirao, Tomoko |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Yukimi |e verfasserin |4 aut | |
| 700 | 1 | |a Morita, Kohei |e verfasserin |4 aut | |
| 700 | 1 | |a Fujii, Tomomi |e verfasserin |4 aut | |
| 700 | 1 | |a Ohbayashi, Chiho |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Toyoki |e verfasserin |4 aut | |
| 700 | 1 | |a Sho, Masayuki |e verfasserin |4 aut | |
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