'Two countries-two labs' : the transnational gamete donation (TGD) programme to support egg donation
PURPOSE: To evaluate the effectiveness, efficiency, and safety of a transnational gamete donation (TGD) programme based on the shipping of vitrified donor oocytes.
METHODS: A retro-prospective observational study was conducted in the Assisted Reproductive Technology Center of the University Hospital of Florence, Italy. The study population included 622 consecutive donor oocyte cycles. A mean number of 6 vitrified oocytes per couple were shipped from two Spanish biobanks. In the receiving centre, gametes were warmed and inseminated and the subsequent embryo transfer (ET) was performed. The main outcome measurement was LBR. Secondary outcomes included oocyte survival rate, ICSI damage rate, normal fertilization, cleavage, and implantation rate (IR) in both 'fresh' and cryotransfer cycles.
RESULTS: A total number of 3536 mature oocytes were warmed with 81.4% surviving oocytes. 2PN oocytes were 1941 with an ICSI normal fertilization rate of 70.4% and a cleavage rate of 93.4%; 857 day-3 embryos were transferred in 498 women, 63 blastocysts in 44. Couples with at least one vitrified embryo were 181 (32.3%). IR was 25.1% and 33.1% for day-3 ET and blastocyst stage respectively. Crude pregnancy rate and LBR after the first ET were 35.5% and 27% correspondingly with a conservative cumulative LBR of 34% and an optimal LBR of 51.4%.
CONCLUSION: Imported vitrified donor oocytes retain their competence and are capable of resulting in ongoing pregnancies and healthy babies in a proportion comparable to other existing systems as egg donation with vitrification/warming in the same laboratory and transnational fresh oocyte donation.
| Errataetall: |
ErratumIn: J Assist Reprod Genet. 2024 Jan 3;:. - PMID 38167786 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Journal of assisted reproduction and genetics - 37(2020), 12 vom: 21. Dez., Seite 3039-3049 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Coccia, Maria Elisabetta [VerfasserIn] |
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| Links: |
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| Themen: |
Assisted reproduction |
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| Anmerkungen: |
Date Completed 05.07.2021 Date Revised 05.01.2024 published: Print-Electronic ErratumIn: J Assist Reprod Genet. 2024 Jan 3;:. - PMID 38167786 Citation Status MEDLINE |
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| doi: |
10.1007/s10815-020-01961-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a ErratumIn: J Assist Reprod Genet. 2024 Jan 3;:. - PMID 38167786 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: To evaluate the effectiveness, efficiency, and safety of a transnational gamete donation (TGD) programme based on the shipping of vitrified donor oocytes | ||
| 520 | |a METHODS: A retro-prospective observational study was conducted in the Assisted Reproductive Technology Center of the University Hospital of Florence, Italy. The study population included 622 consecutive donor oocyte cycles. A mean number of 6 vitrified oocytes per couple were shipped from two Spanish biobanks. In the receiving centre, gametes were warmed and inseminated and the subsequent embryo transfer (ET) was performed. The main outcome measurement was LBR. Secondary outcomes included oocyte survival rate, ICSI damage rate, normal fertilization, cleavage, and implantation rate (IR) in both 'fresh' and cryotransfer cycles | ||
| 520 | |a RESULTS: A total number of 3536 mature oocytes were warmed with 81.4% surviving oocytes. 2PN oocytes were 1941 with an ICSI normal fertilization rate of 70.4% and a cleavage rate of 93.4%; 857 day-3 embryos were transferred in 498 women, 63 blastocysts in 44. Couples with at least one vitrified embryo were 181 (32.3%). IR was 25.1% and 33.1% for day-3 ET and blastocyst stage respectively. Crude pregnancy rate and LBR after the first ET were 35.5% and 27% correspondingly with a conservative cumulative LBR of 34% and an optimal LBR of 51.4% | ||
| 520 | |a CONCLUSION: Imported vitrified donor oocytes retain their competence and are capable of resulting in ongoing pregnancies and healthy babies in a proportion comparable to other existing systems as egg donation with vitrification/warming in the same laboratory and transnational fresh oocyte donation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Assisted reproduction | |
| 650 | 4 | |a Cryo-bank | |
| 650 | 4 | |a Cumulative live birth | |
| 650 | 4 | |a Egg donation | |
| 650 | 4 | |a Infertility | |
| 650 | 4 | |a Oocyte vitrification | |
| 700 | 1 | |a Rizzello, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Wakunga, Savio |e verfasserin |4 aut | |
| 700 | 1 | |a Badolato, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Evangelisti, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Bertocci, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Giachini, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Criscuoli, Luciana |e verfasserin |4 aut | |
| 700 | 1 | |a Micelli, Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Picone, Rita |e verfasserin |4 aut | |
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