Reactivation of SARS-CoV-2 after Asymptomatic Infection while on High-Dose Corticosteroids. Case Report
© Springer Nature Switzerland AG 2020..
As SARS-CoV-2 and its related clinical syndrome (COVID-19) became a pandemic worldwide, questions regarding its clinical presentation, infectivity, and immune response have been the subject of investigation. We present a case of a patient previously considered recovered from nosocomially transmitted asymptomatic COVID-19 illness, who presented with new respiratory, radiological, and RT-PCR findings consistent with COVID-19, while on high-dose prednisolone due to a suspected secondary demyelinating disease. Importantly, it led to three subsequent cases within patient's household after discharge from the hospital. After reviewing this case in light of current evidence and debates surrounding SARS-CoV-2 RT-PCR results, we hypothesize that patients on corticosteroids may have particular viral shedding dynamics and should prompt a more conservative approach in regard to isolation discontinuation and monitoring.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
---|---|
Enthalten in: |
SN comprehensive clinical medicine - 2(2020), 11 vom: 30., Seite 2402-2405 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Patrocínio de Jesus, Rita [VerfasserIn] |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Revised 18.02.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.1007/s42399-020-00548-x |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM316130745 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM316130745 | ||
003 | DE-627 | ||
005 | 20231225160420.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s42399-020-00548-x |2 doi | |
028 | 5 | 2 | |a pubmed24n1053.xml |
035 | |a (DE-627)NLM316130745 | ||
035 | |a (NLM)33043249 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Patrocínio de Jesus, Rita |e verfasserin |4 aut | |
245 | 1 | 0 | |a Reactivation of SARS-CoV-2 after Asymptomatic Infection while on High-Dose Corticosteroids. Case Report |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 18.02.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a © Springer Nature Switzerland AG 2020. | ||
520 | |a As SARS-CoV-2 and its related clinical syndrome (COVID-19) became a pandemic worldwide, questions regarding its clinical presentation, infectivity, and immune response have been the subject of investigation. We present a case of a patient previously considered recovered from nosocomially transmitted asymptomatic COVID-19 illness, who presented with new respiratory, radiological, and RT-PCR findings consistent with COVID-19, while on high-dose prednisolone due to a suspected secondary demyelinating disease. Importantly, it led to three subsequent cases within patient's household after discharge from the hospital. After reviewing this case in light of current evidence and debates surrounding SARS-CoV-2 RT-PCR results, we hypothesize that patients on corticosteroids may have particular viral shedding dynamics and should prompt a more conservative approach in regard to isolation discontinuation and monitoring | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a Case report | |
650 | 4 | |a Corticosteroids | |
650 | 4 | |a RT-PCR | |
650 | 4 | |a Viral shedding | |
700 | 1 | |a Silva, Raquel |e verfasserin |4 aut | |
700 | 1 | |a Aliyeva, Elzara |e verfasserin |4 aut | |
700 | 1 | |a Lopes, Luís |e verfasserin |4 aut | |
700 | 1 | |a Portugalyan, Mihran |e verfasserin |4 aut | |
700 | 1 | |a Antunes, Liliana |e verfasserin |4 aut | |
700 | 1 | |a Diaz, Priscila |e verfasserin |4 aut | |
700 | 1 | |a Costa, Carolina |e verfasserin |4 aut | |
700 | 1 | |a Araújo, Ana Carolina |e verfasserin |4 aut | |
700 | 1 | |a Coelho, Sílvia |e verfasserin |4 aut | |
700 | 1 | |a Mendes, João João |e verfasserin |4 aut | |
700 | 1 | |a Gomes, Sara |e verfasserin |4 aut | |
700 | 1 | |a Serra, Isabel |e verfasserin |4 aut | |
700 | 1 | |a Freitas, Paulo |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t SN comprehensive clinical medicine |d 2019 |g 2(2020), 11 vom: 30., Seite 2402-2405 |w (DE-627)NLM300071965 |x 2523-8973 |7 nnns |
773 | 1 | 8 | |g volume:2 |g year:2020 |g number:11 |g day:30 |g pages:2402-2405 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s42399-020-00548-x |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 2 |j 2020 |e 11 |b 30 |h 2402-2405 |