Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals
Copyright © 2020 Elsevier Inc. All rights reserved..
In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission and mammalian adaptation of this influenza A virus, revealing changes in the hemagglutinin surface protein that increase stability and receptor binding. The seal A/H10N7 virus was aerosol or respiratory droplet transmissible between ferrets. Compared with avian H10 hemagglutinin, seal H10 hemagglutinin showed stronger binding to the human-type sialic acid receptor, with preferential binding to α2,6-linked sialic acids on long extended branches. In X-ray structures, changes in the 220-loop of the receptor-binding pocket caused similar interactions with human receptor as seen for pandemic strains. Two substitutions made seal H10 hemagglutinin more stable than avian H10 hemagglutinin and similar to human hemagglutinin. Consequently, identification of avian-origin influenza viruses across mammals appears critical to detect influenza A viruses posing a major threat to humans and other mammals.
| Errataetall: |
CommentIn: Cell Host Microbe. 2020 Oct 7;28(4):506-508. - PMID 33031768 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Cell host & microbe - 28(2020), 4 vom: 07. Okt., Seite 602-613.e7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Herfst, Sander [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 24.05.2021 Date Revised 08.10.2021 published: Print CommentIn: Cell Host Microbe. 2020 Oct 7;28(4):506-508. - PMID 33031768 Citation Status MEDLINE |
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| doi: |
10.1016/j.chom.2020.08.011 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316018112 |
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| 500 | |a CommentIn: Cell Host Microbe. 2020 Oct 7;28(4):506-508. - PMID 33031768 | ||
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| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission and mammalian adaptation of this influenza A virus, revealing changes in the hemagglutinin surface protein that increase stability and receptor binding. The seal A/H10N7 virus was aerosol or respiratory droplet transmissible between ferrets. Compared with avian H10 hemagglutinin, seal H10 hemagglutinin showed stronger binding to the human-type sialic acid receptor, with preferential binding to α2,6-linked sialic acids on long extended branches. In X-ray structures, changes in the 220-loop of the receptor-binding pocket caused similar interactions with human receptor as seen for pandemic strains. Two substitutions made seal H10 hemagglutinin more stable than avian H10 hemagglutinin and similar to human hemagglutinin. Consequently, identification of avian-origin influenza viruses across mammals appears critical to detect influenza A viruses posing a major threat to humans and other mammals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a A/H10N7 | |
| 650 | 4 | |a aerosol | |
| 650 | 4 | |a glycan microarrays | |
| 650 | 4 | |a hemagglutinin | |
| 650 | 4 | |a influenza | |
| 650 | 4 | |a receptor-binding | |
| 650 | 4 | |a respiratory droplet | |
| 650 | 4 | |a stability | |
| 650 | 4 | |a transmission | |
| 650 | 7 | |a Aerosols |2 NLM | |
| 650 | 7 | |a Hemagglutinin Glycoproteins, Influenza Virus |2 NLM | |
| 650 | 7 | |a Polysaccharides |2 NLM | |
| 650 | 7 | |a Sialic Acids |2 NLM | |
| 700 | 1 | |a Zhang, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Richard, Mathilde |e verfasserin |4 aut | |
| 700 | 1 | |a McBride, Ryan |e verfasserin |4 aut | |
| 700 | 1 | |a Lexmond, Pascal |e verfasserin |4 aut | |
| 700 | 1 | |a Bestebroer, Theo M |e verfasserin |4 aut | |
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| 700 | 1 | |a Bodewes, Rogier |e verfasserin |4 aut | |
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| 700 | 1 | |a Skehel, John J |e verfasserin |4 aut | |
| 700 | 1 | |a Fouchier, Ron A M |e verfasserin |4 aut | |
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