Medication-related problems in older people in Catalonia : A real-world data study
© 2020 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd..
PURPOSE: The aim of this study was to determine medication-related problems (MRPs) in primary care patients over 65 years of age.
METHODS: Cross-sectional study based on the electronic health records of patients (65-99 years of age) visited in 284 primary health care centers during 2012 in Catalonia.
VARIABLES: age, sex, sociodemographic variables, number of drugs, kidney and liver function and MRPs (duplicate therapy, drug-drug interactions, potentially inappropriate medications [PIMs] and drugs contraindicated in chronic kidney disease and in liver diseases). Unconditional logistic regression models were used to identify the factors associated with MRPs in patients with multimorbidity.
RESULTS: 916 619 older people were included and 853 085 of them met the criteria for multimorbidity. Median age was 75 years and 57.7% of them were women. High percentages of MRPs were observed: PIMs (62.8%), contraindicated drugs in chronic kidney disease (12.1%), duplicate therapy (11.1%), contraindicated drugs in liver diseases (4.2%), and drug-drug interactions (1.0%). These numbers were higher in the subgroup of patients with ≥10 diseases. The most common PIMs were connected to drugs that increase the risk of fall (66.8%), antiulcer agents without criteria for gastroprotection (40.6%), and the combination of drugs with anticholinergic effects (39.7%). In the multivariate analysis, the variables associated with all MRPs among the patients with multimorbidity were the number of drugs and the number of visits.
CONCLUSIONS: The coexistence of multimorbidity and polypharmacy is associated with an elevated risk of MRPs in older people. Medication safety for older patients constitutes a pressing concern for health services.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Pharmacoepidemiology and drug safety - 30(2021), 2 vom: 07. Feb., Seite 220-228 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Troncoso-Mariño, Amelia [VerfasserIn] |
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| Links: |
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| Themen: |
Contraindicated drugs |
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| Anmerkungen: |
Date Completed 24.11.2021 Date Revised 10.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/pds.5149 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM315962798 |
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| 100 | 1 | |a Troncoso-Mariño, Amelia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Medication-related problems in older people in Catalonia |b A real-world data study |
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| 500 | |a Date Revised 10.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd. | ||
| 520 | |a PURPOSE: The aim of this study was to determine medication-related problems (MRPs) in primary care patients over 65 years of age | ||
| 520 | |a METHODS: Cross-sectional study based on the electronic health records of patients (65-99 years of age) visited in 284 primary health care centers during 2012 in Catalonia | ||
| 520 | |a VARIABLES: age, sex, sociodemographic variables, number of drugs, kidney and liver function and MRPs (duplicate therapy, drug-drug interactions, potentially inappropriate medications [PIMs] and drugs contraindicated in chronic kidney disease and in liver diseases). Unconditional logistic regression models were used to identify the factors associated with MRPs in patients with multimorbidity | ||
| 520 | |a RESULTS: 916 619 older people were included and 853 085 of them met the criteria for multimorbidity. Median age was 75 years and 57.7% of them were women. High percentages of MRPs were observed: PIMs (62.8%), contraindicated drugs in chronic kidney disease (12.1%), duplicate therapy (11.1%), contraindicated drugs in liver diseases (4.2%), and drug-drug interactions (1.0%). These numbers were higher in the subgroup of patients with ≥10 diseases. The most common PIMs were connected to drugs that increase the risk of fall (66.8%), antiulcer agents without criteria for gastroprotection (40.6%), and the combination of drugs with anticholinergic effects (39.7%). In the multivariate analysis, the variables associated with all MRPs among the patients with multimorbidity were the number of drugs and the number of visits | ||
| 520 | |a CONCLUSIONS: The coexistence of multimorbidity and polypharmacy is associated with an elevated risk of MRPs in older people. Medication safety for older patients constitutes a pressing concern for health services | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a contraindicated drugs | |
| 650 | 4 | |a drug interactions | |
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| 650 | 4 | |a multimorbidity | |
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| 650 | 4 | |a pharmacoepidemiology | |
| 700 | 1 | |a López-Jiménez, Tomás |e verfasserin |4 aut | |
| 700 | 1 | |a Roso-Llorach, Albert |e verfasserin |4 aut | |
| 700 | 1 | |a Villén, Noemí |e verfasserin |4 aut | |
| 700 | 1 | |a Amado-Guirado, Ester |e verfasserin |4 aut | |
| 700 | 1 | |a Guisado-Clavero, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Bertolin, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Pons Vigues, Mariona |e verfasserin |4 aut | |
| 700 | 1 | |a Foguet-Boreu, Quintí |e verfasserin |4 aut | |
| 700 | 1 | |a Violán, Concepción |e verfasserin |4 aut | |
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