COVID-19-Related Anosmia : The Olfactory Pathway Hypothesis and Early Intervention
Copyright © 2020 Gori, Leone, Loffredo, Cinicola, Brindisi, De Castro, Spalice, Duse and Zicari..
Anosmia is a well-described symptom of Corona Virus Disease 2019 (COVID-19). Several respiratory viruses are able to cause post-viral olfactory dysfunction, suggesting a sensorineural damage. Since the olfactory bulb is considered an immunological organ contributing to prevent the invasion of viruses, it could have a role in host defense. The inflammatory products locally released in COVID-19, leading to a local damage and causing olfactory loss, simultaneously may interfere with the viral spread into the central nervous system. In this context, olfactory receptors could play a role as an alternative way of SARS-CoV-2 entry into cells locally, in the central nervous system, and systemically. Differences in olfactory bulb due to sex and age may contribute to clarify the different susceptibility to infection and understand the role of age in transmission and disease severity. Finally, evaluation of the degree of functional impairment (grading), central/peripheral anosmia (localization), and the temporal course (evolution) may be useful tools to counteract COVID-19.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Frontiers in neurology - 11(2020) vom: 25., Seite 956 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gori, Alessandra [VerfasserIn] |
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| Links: |
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| Themen: |
Anosmia |
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| Anmerkungen: |
Date Revised 04.11.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fneur.2020.00956 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM315839228 |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2020 Gori, Leone, Loffredo, Cinicola, Brindisi, De Castro, Spalice, Duse and Zicari. | ||
| 520 | |a Anosmia is a well-described symptom of Corona Virus Disease 2019 (COVID-19). Several respiratory viruses are able to cause post-viral olfactory dysfunction, suggesting a sensorineural damage. Since the olfactory bulb is considered an immunological organ contributing to prevent the invasion of viruses, it could have a role in host defense. The inflammatory products locally released in COVID-19, leading to a local damage and causing olfactory loss, simultaneously may interfere with the viral spread into the central nervous system. In this context, olfactory receptors could play a role as an alternative way of SARS-CoV-2 entry into cells locally, in the central nervous system, and systemically. Differences in olfactory bulb due to sex and age may contribute to clarify the different susceptibility to infection and understand the role of age in transmission and disease severity. Finally, evaluation of the degree of functional impairment (grading), central/peripheral anosmia (localization), and the temporal course (evolution) may be useful tools to counteract COVID-19 | ||
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| 700 | 1 | |a Leone, Fabrizio |e verfasserin |4 aut | |
| 700 | 1 | |a Loffredo, Lorenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Cinicola, Bianca Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Brindisi, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a De Castro, Giovanna |e verfasserin |4 aut | |
| 700 | 1 | |a Spalice, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Duse, Marzia |e verfasserin |4 aut | |
| 700 | 1 | |a Zicari, Anna Maria |e verfasserin |4 aut | |
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