High terminal creatinine donors should not preclude simultaneous kidney and pancreas transplantation
Copyright © 2020 Elsevier Inc. All rights reserved..
BACKGROUND: Simultaneous pancreas and kidney transplantation (SPK) in the setting of end-stage renal disease offers unmatched outcomes in insulin dependent diabetic patients. Donor pool expansion through the transplantation of kidneys with acute kidney injury (AKI) is controversial.
METHODS: 59 SPK transplants were classified by presence of donor AKI, defined as donor terminal creatinine ≥ 1.5x the initial creatinine or donor terminal creatinine > 4.0 mg/dL. Endpoints included graft and patient survival, delayed graft function (DGF), serum creatinine, glomerular filtration rate (GFR), Hemoglobin A1c (HbA1c) and acute rejection.
RESULTS: The donor AKI group (n = 35) had significantly higher rates of DGF (38 v. 9%, p = 0.01). There was no difference in creatinine or GFR at 1, 3, 6 and 12 months. HbA1c was comparable at 3, 6 and 12 months. There was no significant difference in the percentage of patients that required anti-diabetic agents after transplant (14 v. 4%, p = 0.56).
CONCLUSIONS: We observed increased rates of DGF in SPK recipients with donor AKI. However, equivalent outcomes of pancreas and kidney function in both groups were observed.
| Errataetall: |
CommentIn: Am J Surg. 2021 Apr;221(4):675-676. - PMID 33454024 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:221 |
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| Enthalten in: |
American journal of surgery - 221(2021), 4 vom: 15. Apr., Seite 677-680 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Torabi, Julia [VerfasserIn] |
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| Links: |
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| Themen: |
AYI8EX34EU |
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Date Completed 12.05.2021 Date Revised 12.05.2021 published: Print-Electronic CommentIn: Am J Surg. 2021 Apr;221(4):675-676. - PMID 33454024 Citation Status MEDLINE |
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| doi: |
10.1016/j.amjsurg.2020.09.031 |
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| PPN (Katalog-ID): |
NLM315827874 |
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| 500 | |a CommentIn: Am J Surg. 2021 Apr;221(4):675-676. - PMID 33454024 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Simultaneous pancreas and kidney transplantation (SPK) in the setting of end-stage renal disease offers unmatched outcomes in insulin dependent diabetic patients. Donor pool expansion through the transplantation of kidneys with acute kidney injury (AKI) is controversial | ||
| 520 | |a METHODS: 59 SPK transplants were classified by presence of donor AKI, defined as donor terminal creatinine ≥ 1.5x the initial creatinine or donor terminal creatinine > 4.0 mg/dL. Endpoints included graft and patient survival, delayed graft function (DGF), serum creatinine, glomerular filtration rate (GFR), Hemoglobin A1c (HbA1c) and acute rejection | ||
| 520 | |a RESULTS: The donor AKI group (n = 35) had significantly higher rates of DGF (38 v. 9%, p = 0.01). There was no difference in creatinine or GFR at 1, 3, 6 and 12 months. HbA1c was comparable at 3, 6 and 12 months. There was no significant difference in the percentage of patients that required anti-diabetic agents after transplant (14 v. 4%, p = 0.56) | ||
| 520 | |a CONCLUSIONS: We observed increased rates of DGF in SPK recipients with donor AKI. However, equivalent outcomes of pancreas and kidney function in both groups were observed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Delayed graft function | |
| 650 | 4 | |a Donor acute kidney injury | |
| 650 | 4 | |a Graft function | |
| 650 | 4 | |a Simultaneous pancreas kidney transplantation | |
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| 700 | 1 | |a Rechnitzer, Alma |e verfasserin |4 aut | |
| 700 | 1 | |a Rocca, Juan P |e verfasserin |4 aut | |
| 700 | 1 | |a Ajaimy, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Lirano-Ward, Luz |e verfasserin |4 aut | |
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| 700 | 1 | |a Graham, Jay A |e verfasserin |4 aut | |
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