Clinical characteristics, symptoms and outcomes of 1054 adults presenting to hospital with suspected COVID-19 : A comparison of patients with and without SARS-CoV-2 infection
Copyright © 2020. Published by Elsevier Ltd..
OBJECTIVES: Most reports describing the characteristics of patients hospitalised with COVID-19 lack a comparator group. We compared clinical characteristics, symptoms, and outcomes of adults presenting to hospital during the pandemic first wave, who tested positive and negative for SARS-CoV-2.
METHODS: Detailed patient data was obtained from a large, controlled, non-randomised trial of molecular point-of-care testing versus laboratory RT-PCR for SARS-CoV-2 in adults presenting to a large UK hospital with suspected COVID-19.
RESULTS: 1054 patients were included: 352 (33.4%) tested positive and 702 (66.6%) negative. 13.4% (47/352) COVID-19-positive patients had COPD versus 18.7% (131/702) of COVID-19-negative patients (difference=5.3% [95%CI -9.7% to -0.5%], p = 0.0297). 5.7% (20/352) of COVID-19-positive patients were smokers versus 16.5% (116/702) of negative patients (difference=-10.8% [-14.4% to -7.0%], p = 0.0001). 70.5% (248/352) of COVID-19-positive patients were White-British versus 85.5% (600/702) of negative patients (difference=-15.0% [-20.5% to -9.7%], p<0.0001). 20.9% (39/187) of COVID-19-positive patients were healthcare workers versus 5.2% (15/287) of negative patients (p<0.0001). Anosmia was reported in 33.1% (47/142) versus 8.8% (19/216) of COVID-19-positive and negative patients respectively (p<0.0001). Non-SARS-CoV-2 respiratory viruses or atypical bacteria were detected in 2.5% (5/197) of COVID-19 patients versus 7.9% (24/302) of COVID-19-negative patients (p = 0.0109). Hospitalisation duration and 30-day-mortality were higher in COVID-19 patients and invasive ventilation was more frequent (11.1% vs 2.8%, p<0.0001), and longer (14.5 vs 4.7 days, p = 0.0015).
CONCLUSIONS: There were substantial differences between patients with and without COVID-19 in terms of ethnicity, healthcare worker-status, comorbidities, symptoms, and outcomes. These data can inform healthcare planning for the next phase of the pandemic.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:81 |
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| Enthalten in: |
The Journal of infection - 81(2020), 6 vom: 20. Dez., Seite 937-943 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Brendish, Nathan J [VerfasserIn] |
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| Links: |
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| Themen: |
COPD |
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| Anmerkungen: |
Date Completed 07.01.2021 Date Revised 04.12.2021 published: Print-Electronic CommentIn: J Infect. 2021 Apr;82(4):84-123. - PMID 33197474 Citation Status MEDLINE |
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| doi: |
10.1016/j.jinf.2020.09.033 |
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| funding: |
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| PPN (Katalog-ID): |
NLM315685514 |
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| 100 | 1 | |a Brendish, Nathan J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical characteristics, symptoms and outcomes of 1054 adults presenting to hospital with suspected COVID-19 |b A comparison of patients with and without SARS-CoV-2 infection |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 07.01.2021 | ||
| 500 | |a Date Revised 04.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: J Infect. 2021 Apr;82(4):84-123. - PMID 33197474 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020. Published by Elsevier Ltd. | ||
| 520 | |a OBJECTIVES: Most reports describing the characteristics of patients hospitalised with COVID-19 lack a comparator group. We compared clinical characteristics, symptoms, and outcomes of adults presenting to hospital during the pandemic first wave, who tested positive and negative for SARS-CoV-2 | ||
| 520 | |a METHODS: Detailed patient data was obtained from a large, controlled, non-randomised trial of molecular point-of-care testing versus laboratory RT-PCR for SARS-CoV-2 in adults presenting to a large UK hospital with suspected COVID-19 | ||
| 520 | |a RESULTS: 1054 patients were included: 352 (33.4%) tested positive and 702 (66.6%) negative. 13.4% (47/352) COVID-19-positive patients had COPD versus 18.7% (131/702) of COVID-19-negative patients (difference=5.3% [95%CI -9.7% to -0.5%], p = 0.0297). 5.7% (20/352) of COVID-19-positive patients were smokers versus 16.5% (116/702) of negative patients (difference=-10.8% [-14.4% to -7.0%], p = 0.0001). 70.5% (248/352) of COVID-19-positive patients were White-British versus 85.5% (600/702) of negative patients (difference=-15.0% [-20.5% to -9.7%], p<0.0001). 20.9% (39/187) of COVID-19-positive patients were healthcare workers versus 5.2% (15/287) of negative patients (p<0.0001). Anosmia was reported in 33.1% (47/142) versus 8.8% (19/216) of COVID-19-positive and negative patients respectively (p<0.0001). Non-SARS-CoV-2 respiratory viruses or atypical bacteria were detected in 2.5% (5/197) of COVID-19 patients versus 7.9% (24/302) of COVID-19-negative patients (p = 0.0109). Hospitalisation duration and 30-day-mortality were higher in COVID-19 patients and invasive ventilation was more frequent (11.1% vs 2.8%, p<0.0001), and longer (14.5 vs 4.7 days, p = 0.0015) | ||
| 520 | |a CONCLUSIONS: There were substantial differences between patients with and without COVID-19 in terms of ethnicity, healthcare worker-status, comorbidities, symptoms, and outcomes. These data can inform healthcare planning for the next phase of the pandemic | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COPD | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Clinical characteristics | |
| 650 | 4 | |a Cohort | |
| 650 | 4 | |a Healthcare workers | |
| 650 | 4 | |a Outcomes | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Smokers | |
| 650 | 4 | |a Symptoms | |
| 700 | 1 | |a Poole, Stephen |e verfasserin |4 aut | |
| 700 | 1 | |a Naidu, Vasanth V |e verfasserin |4 aut | |
| 700 | 1 | |a Mansbridge, Christopher T |e verfasserin |4 aut | |
| 700 | 1 | |a Norton, Nicholas |e verfasserin |4 aut | |
| 700 | 1 | |a Borca, Florina |e verfasserin |4 aut | |
| 700 | 1 | |a Phan, Hang Tt |e verfasserin |4 aut | |
| 700 | 1 | |a Wheeler, Helen |e verfasserin |4 aut | |
| 700 | 1 | |a Harvey, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Presland, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Clark, Tristan W |e verfasserin |4 aut | |
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