Potential pharmacodynamic and pharmacokinetic interactions of Nigella Sativa and Trigonella Foenum-graecum with losartan in L-NAME induced hypertensive rats
© 2020 The Author(s)..
The objective of this investigation was to study whether Nigella Sativa and Trigonella Foenum-graecum, could modulate the losartan pharmacodynamic (PD) and pharmacokinetic (PK) in experimental L-NAME induced hypertensive rats. For in vivo study, the systolic blood pressure (SBP) of rats was measured by the "tail-cuff system" after the treatment of rats with herb alone and herb + losartan in hypertensive rats. The SBP of rats treated with L-NAME + losartan also recorded. For the PK study, blood samples were obtained for up to 12 h to determine the concentrations of the drug, and various PK parameters were calculated. The data displayed that the SBP was significantly (p < 0.05) decreased in the rats when administered with L-NAME + N. Sativa or L-NAME + T. Foenum-graecum in contrast to the rats administered with L-NAME alone. A more prominent decline (p < 0.05) in SBP was detected in rats administered with L-NAME + N. Sativa + losartan and L-NAME + T. Foenum-graecum + losartan. In a PK study, higher losartan Cmax and AUC0-t were noted in rats treated with N. Sativa + losartan and T. Foenum-graecum + losartan, although the difference was not significant in contrast to the control group. This study proposed that the interaction between N. Sativa & losartan and T. Foenum-graecum & losartan could take place on concurrent administration; consequently, the dose of losartan may need to be accustomed when they are utilized simultaneously.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Saudi journal of biological sciences - 27(2020), 10 vom: 21. Okt., Seite 2544-2550 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ahad, Abdul [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Revised 02.10.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.sjbs.2020.05.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM315652799 |
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| 100 | 1 | |a Ahad, Abdul |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Potential pharmacodynamic and pharmacokinetic interactions of Nigella Sativa and Trigonella Foenum-graecum with losartan in L-NAME induced hypertensive rats |
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| 500 | |a Date Revised 02.10.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2020 The Author(s). | ||
| 520 | |a The objective of this investigation was to study whether Nigella Sativa and Trigonella Foenum-graecum, could modulate the losartan pharmacodynamic (PD) and pharmacokinetic (PK) in experimental L-NAME induced hypertensive rats. For in vivo study, the systolic blood pressure (SBP) of rats was measured by the "tail-cuff system" after the treatment of rats with herb alone and herb + losartan in hypertensive rats. The SBP of rats treated with L-NAME + losartan also recorded. For the PK study, blood samples were obtained for up to 12 h to determine the concentrations of the drug, and various PK parameters were calculated. The data displayed that the SBP was significantly (p < 0.05) decreased in the rats when administered with L-NAME + N. Sativa or L-NAME + T. Foenum-graecum in contrast to the rats administered with L-NAME alone. A more prominent decline (p < 0.05) in SBP was detected in rats administered with L-NAME + N. Sativa + losartan and L-NAME + T. Foenum-graecum + losartan. In a PK study, higher losartan Cmax and AUC0-t were noted in rats treated with N. Sativa + losartan and T. Foenum-graecum + losartan, although the difference was not significant in contrast to the control group. This study proposed that the interaction between N. Sativa & losartan and T. Foenum-graecum & losartan could take place on concurrent administration; consequently, the dose of losartan may need to be accustomed when they are utilized simultaneously | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a L-NAME | |
| 650 | 4 | |a Losartan | |
| 650 | 4 | |a Nigella Sativa | |
| 650 | 4 | |a Pharmacodynamic | |
| 650 | 4 | |a Pharmacokinetic | |
| 650 | 4 | |a Trigonella Foenum-graecum | |
| 700 | 1 | |a Raish, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Bin Jardan, Yousef A |e verfasserin |4 aut | |
| 700 | 1 | |a Alam, Mohd Aftab |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Mohizea, Abdullah M |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Jenoobi, Fahad I |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:27 |g year:2020 |g number:10 |g day:21 |g month:10 |g pages:2544-2550 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.sjbs.2020.05.009 |3 Volltext |
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