An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy
For patients with drug-resistant focal epilepsy, excision of the epileptogenic zone is the most effective treatment approach. However, the surgery is less effective in the 15-30% of patients whose lesions are not distinct when visualized by magnetic resonance imaging (MRI). Here, we show that an intravenously administered MRI contrast agent consisting of a paramagnetic polymer coating encapsulating a superparamagnetic cluster of ultrasmall superparamagnetic iron oxide crosses the blood-brain barrier and improves lesion visualization with high sensitivity and target-to-background ratio. In kainic-acid-induced mouse models of drug-resistant focal epilepsy, electric-field changes in the brain associated with seizures trigger breakdown of the contrast agent, restoring the T1-weighted magnetic resonance signal, which otherwise remains quenched due to the distance-dependent magnetic resonance tuning effect between the cluster and the coating. The electric-field-responsive contrast agent may increase the probability of detecting seizure foci in patients and facilitate the study of brain diseases associated with epilepsy.
| Errataetall: |
CommentIn: Nat Biomed Eng. 2021 Mar;5(3):199-200. - PMID 33727711 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Nature biomedical engineering - 5(2021), 3 vom: 29. März, Seite 278-289 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Cong [VerfasserIn] |
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| Links: |
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| Themen: |
1K09F3G675 |
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| Anmerkungen: |
Date Completed 12.04.2021 Date Revised 28.09.2021 published: Print-Electronic CommentIn: Nat Biomed Eng. 2021 Mar;5(3):199-200. - PMID 33727711 Citation Status MEDLINE |
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| doi: |
10.1038/s41551-020-00618-4 |
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NLM315599596 |
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| 245 | 1 | 3 | |a An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy |
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| 520 | |a For patients with drug-resistant focal epilepsy, excision of the epileptogenic zone is the most effective treatment approach. However, the surgery is less effective in the 15-30% of patients whose lesions are not distinct when visualized by magnetic resonance imaging (MRI). Here, we show that an intravenously administered MRI contrast agent consisting of a paramagnetic polymer coating encapsulating a superparamagnetic cluster of ultrasmall superparamagnetic iron oxide crosses the blood-brain barrier and improves lesion visualization with high sensitivity and target-to-background ratio. In kainic-acid-induced mouse models of drug-resistant focal epilepsy, electric-field changes in the brain associated with seizures trigger breakdown of the contrast agent, restoring the T1-weighted magnetic resonance signal, which otherwise remains quenched due to the distance-dependent magnetic resonance tuning effect between the cluster and the coating. The electric-field-responsive contrast agent may increase the probability of detecting seizure foci in patients and facilitate the study of brain diseases associated with epilepsy | ||
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| 700 | 1 | |a Zhang, Jianping |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Qinghua |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Xingyu |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Dandan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Haoran |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Xihui |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Haiyan |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Zhaobing |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jianhong |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Zixuan |e verfasserin |4 aut | |
| 700 | 1 | |a Long, Nicholas J |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Cong |e verfasserin |4 aut | |
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