The Association between Serum Bilirubin Levels and Colorectal Cancer Risk : Results from the Prospective Cooperative Health Research in the Region of Augsburg (KORA) Study in Germany
Emerging studies have suggested that bilirubin, particularly unconjugated bilirubin (UCB), has substantial anti-inflammatory and antioxidant properties that protect against oxidative stress-associated diseases such as cancer. Few observational studies have investigated the etiological role of bilirubin in colorectal cancer (CRC) development. In this case-control study, nested in the population-based prospective cohort of the Cooperative Health Research in the Region of Augsburg (KORA) study in south Germany, pre-diagnostic circulating UCB concentrations were measured by high-performance liquid chromatography in 77 CRC cases and their individually matched controls. Multivariable unconditional logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for associations between log-transformed UCB levels (log-UCB), standardized per one-standard-deviation (one-SD) increment, and CRC risk. The models were a priori stratified by sex based on previous evidence. In the fully adjusted models, each one-SD increment in log-UCB was indicative of a positive association with CRC risk (OR, 1.20; 95% CI, 0.52-2.79) among men, and of an inverse association (OR, 0.76; 95% CI, 0.34-1.84) among women (Pheterogeneity = 0.4 for differences between men and women). We found little evidence for sex-specific associations of circulating bilirubin with CRC risk, and further studies are needed to confirm or refute the potential associations.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
|---|---|
| Enthalten in: |
Antioxidants (Basel, Switzerland) - 9(2020), 10 vom: 24. Sept. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Seyed Khoei, Nazlisadat [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antioxidants |
|---|
| Anmerkungen: |
Date Revised 24.03.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3390/antiox9100908 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM315583940 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM315583940 | ||
| 003 | DE-627 | ||
| 005 | 20240324234445.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/antiox9100908 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1344.xml |
| 035 | |a (DE-627)NLM315583940 | ||
| 035 | |a (NLM)32987702 | ||
| 035 | |a (PII)E908 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Seyed Khoei, Nazlisadat |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Association between Serum Bilirubin Levels and Colorectal Cancer Risk |b Results from the Prospective Cooperative Health Research in the Region of Augsburg (KORA) Study in Germany |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 24.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Emerging studies have suggested that bilirubin, particularly unconjugated bilirubin (UCB), has substantial anti-inflammatory and antioxidant properties that protect against oxidative stress-associated diseases such as cancer. Few observational studies have investigated the etiological role of bilirubin in colorectal cancer (CRC) development. In this case-control study, nested in the population-based prospective cohort of the Cooperative Health Research in the Region of Augsburg (KORA) study in south Germany, pre-diagnostic circulating UCB concentrations were measured by high-performance liquid chromatography in 77 CRC cases and their individually matched controls. Multivariable unconditional logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for associations between log-transformed UCB levels (log-UCB), standardized per one-standard-deviation (one-SD) increment, and CRC risk. The models were a priori stratified by sex based on previous evidence. In the fully adjusted models, each one-SD increment in log-UCB was indicative of a positive association with CRC risk (OR, 1.20; 95% CI, 0.52-2.79) among men, and of an inverse association (OR, 0.76; 95% CI, 0.34-1.84) among women (Pheterogeneity = 0.4 for differences between men and women). We found little evidence for sex-specific associations of circulating bilirubin with CRC risk, and further studies are needed to confirm or refute the potential associations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a KORA | |
| 650 | 4 | |a antioxidants | |
| 650 | 4 | |a bilirubin | |
| 650 | 4 | |a cancer | |
| 650 | 4 | |a colorectal cancer | |
| 650 | 4 | |a unconjugated bilirubin | |
| 700 | 1 | |a Anton, Gabriele |e verfasserin |4 aut | |
| 700 | 1 | |a Peters, Annette |e verfasserin |4 aut | |
| 700 | 1 | |a Freisling, Heinz |e verfasserin |4 aut | |
| 700 | 1 | |a Wagner, Karl-Heinz |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Antioxidants (Basel, Switzerland) |d 2012 |g 9(2020), 10 vom: 24. Sept. |w (DE-627)NLM256601127 |x 2076-3921 |7 nnns |
| 773 | 1 | 8 | |g volume:9 |g year:2020 |g number:10 |g day:24 |g month:09 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/antiox9100908 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 9 |j 2020 |e 10 |b 24 |c 09 | ||