A simplified screening method for short- and medium-chain chlorinated paraffins in food by gas chromatography-low resolution mass spectrometry
Copyright © 2020 Elsevier B.V. All rights reserved..
This study evaluates the performance of a simplified screening method for short- and medium-chain chlorinated paraffins (SCCPs and MCCPs, respectively) based on gas chromatography-electron capture negative ionization/mass spectrometry (GC-ECNI/MS) analysis and chlorine content quantification. The response from different combinations of 'indicator' congener groups present in technical mixture standards were used within calibration calculations to test the hypothesis that ∑SCCPs and ∑MCCPs could be quantified with acceptable accuracy using only a subset of the commonly analysed C10 to C17 and Cl5 to Cl10 groups. Potential combinations were assessed with respect to calibration curve performance and accuracy of SCCP and MCCP analysis of spiked food samples (olive oil, salmon, pork sausage, breakfast cereal, cow's milk and lard). Based on these trials, a screening method which quantifies ∑SCCPs and ∑MCCPs using only congener groups with 6 and 8 chlorine atoms for each carbon chain length was proposed. Concentrations of SCCPs and MCCPs in triplicate analyses of spiked food samples calculated using the proposed screening method deviated by ≤ 25% for the vast majority of samples (maximum deviation 37%) from levels determined using all analysed congener groups. The mean trueness of the screening method as applied to each of the spiked food samples and lard samples from a previous European Union Reference Laboratory (EURL) interlaboratory study ranged from 65 to 110% for ∑SCCPs and 102 to 175% for ∑MCCPs. Relative standard deviations (RSDs) were ≤ 25% for all triplicate analyses and matrix specific LOQs ranged from 0.7 to 6 ng/g ww for ∑SCCPs and from 1.3 to 12 ng/g ww for ∑MCCPs. The proposed screening method has the potential to deliver substantial time savings in instrumental analysis and manual labour without greatly reducing the overall accuracy and sensitivity of SCCP and MCCP quantification.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1631 |
|---|---|
| Enthalten in: |
Journal of chromatography. A - 1631(2020) vom: 08. Nov., Seite 461574 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
McGrath, Thomas J [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
4R7X1O2820 |
|---|
| Anmerkungen: |
Date Completed 24.11.2021 Date Revised 24.11.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.chroma.2020.461574 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM315580062 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM315580062 | ||
| 003 | DE-627 | ||
| 005 | 20231225155223.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.chroma.2020.461574 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1051.xml |
| 035 | |a (DE-627)NLM315580062 | ||
| 035 | |a (NLM)32987312 | ||
| 035 | |a (PII)S0021-9673(20)30849-9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a McGrath, Thomas J |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A simplified screening method for short- and medium-chain chlorinated paraffins in food by gas chromatography-low resolution mass spectrometry |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 24.11.2021 | ||
| 500 | |a Date Revised 24.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a This study evaluates the performance of a simplified screening method for short- and medium-chain chlorinated paraffins (SCCPs and MCCPs, respectively) based on gas chromatography-electron capture negative ionization/mass spectrometry (GC-ECNI/MS) analysis and chlorine content quantification. The response from different combinations of 'indicator' congener groups present in technical mixture standards were used within calibration calculations to test the hypothesis that ∑SCCPs and ∑MCCPs could be quantified with acceptable accuracy using only a subset of the commonly analysed C10 to C17 and Cl5 to Cl10 groups. Potential combinations were assessed with respect to calibration curve performance and accuracy of SCCP and MCCP analysis of spiked food samples (olive oil, salmon, pork sausage, breakfast cereal, cow's milk and lard). Based on these trials, a screening method which quantifies ∑SCCPs and ∑MCCPs using only congener groups with 6 and 8 chlorine atoms for each carbon chain length was proposed. Concentrations of SCCPs and MCCPs in triplicate analyses of spiked food samples calculated using the proposed screening method deviated by ≤ 25% for the vast majority of samples (maximum deviation 37%) from levels determined using all analysed congener groups. The mean trueness of the screening method as applied to each of the spiked food samples and lard samples from a previous European Union Reference Laboratory (EURL) interlaboratory study ranged from 65 to 110% for ∑SCCPs and 102 to 175% for ∑MCCPs. Relative standard deviations (RSDs) were ≤ 25% for all triplicate analyses and matrix specific LOQs ranged from 0.7 to 6 ng/g ww for ∑SCCPs and from 1.3 to 12 ng/g ww for ∑MCCPs. The proposed screening method has the potential to deliver substantial time savings in instrumental analysis and manual labour without greatly reducing the overall accuracy and sensitivity of SCCP and MCCP quantification | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a MCCPs | |
| 650 | 4 | |a SCCPs | |
| 650 | 4 | |a chlorinated paraffins | |
| 650 | 4 | |a food | |
| 650 | 4 | |a gas chromatography | |
| 650 | 4 | |a mass spectrometry | |
| 650 | 7 | |a Hydrocarbons, Chlorinated |2 NLM | |
| 650 | 7 | |a Chlorine |2 NLM | |
| 650 | 7 | |a 4R7X1O2820 |2 NLM | |
| 650 | 7 | |a Paraffin |2 NLM | |
| 650 | 7 | |a 8002-74-2 |2 NLM | |
| 700 | 1 | |a Poma, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a Bombeke, Jasper |e verfasserin |4 aut | |
| 700 | 1 | |a Covaci, Adrian |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of chromatography. A |d 1993 |g 1631(2020) vom: 08. Nov., Seite 461574 |w (DE-627)NLM074731416 |x 1873-3778 |7 nnns |
| 773 | 1 | 8 | |g volume:1631 |g year:2020 |g day:08 |g month:11 |g pages:461574 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.chroma.2020.461574 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 1631 |j 2020 |b 08 |c 11 |h 461574 | ||