Epigenetic approach in obesity : DNA methylation in a prepubertal population which underwent a lifestyle modification
BACKGROUND: Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or cardiovascular disease). MHO is closely related to lifestyle and environmental factors. Epigenetics has become an essential biological tool to analyze the link between obesity and metabolic status. The aim of this study was to determine whether MHO status is conditioned by the DNA methylation (DNAm) of several genes related to lipid metabolism (lipoprotein lipase, retinoid X receptor alpha, liver X receptor, stearoyl-CoA desaturase, sterol regulatory element binding factor 1), and inflammation (LEP) in peripheral blood mononuclear cells (PBMCs) from 131 prepubertal subjects with MHO phenotype after lifestyle modifications with personalized Mediterranean diet (MedDiet) combined with a physical activity (PA) program.
RESULTS: The DNAm of all studied genes were significantly modified in the population after 12 months of lifestyle modifications (MedDiet and PA). In addition, associations were found between the DNAm studies and BMI, homeostatic model assessment of insulin resistance, monounsaturated fatty acid and polyunsaturated fatty acid, moderate-vigorous PA, fat mass, and adherence to MedDiet.
CONCLUSIONS: It was found that DNAm of genes related to lipid metabolism and inflammation are also present in childhood and that this methylation profile can be modified by interventions based on MedDiet and PA.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Clinical epigenetics - 12(2020), 1 vom: 23. Sept., Seite 144 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Gallardo-Escribano, Cristina [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Inflammatory profile |
|---|
| Anmerkungen: |
Date Completed 19.10.2021 Date Revised 12.11.2023 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1186/s13148-020-00935-0 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM315386215 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM315386215 | ||
| 003 | DE-627 | ||
| 005 | 20231225154814.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13148-020-00935-0 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1051.xml |
| 035 | |a (DE-627)NLM315386215 | ||
| 035 | |a (NLM)32967728 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Gallardo-Escribano, Cristina |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Epigenetic approach in obesity |b DNA methylation in a prepubertal population which underwent a lifestyle modification |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 19.10.2021 | ||
| 500 | |a Date Revised 12.11.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or cardiovascular disease). MHO is closely related to lifestyle and environmental factors. Epigenetics has become an essential biological tool to analyze the link between obesity and metabolic status. The aim of this study was to determine whether MHO status is conditioned by the DNA methylation (DNAm) of several genes related to lipid metabolism (lipoprotein lipase, retinoid X receptor alpha, liver X receptor, stearoyl-CoA desaturase, sterol regulatory element binding factor 1), and inflammation (LEP) in peripheral blood mononuclear cells (PBMCs) from 131 prepubertal subjects with MHO phenotype after lifestyle modifications with personalized Mediterranean diet (MedDiet) combined with a physical activity (PA) program | ||
| 520 | |a RESULTS: The DNAm of all studied genes were significantly modified in the population after 12 months of lifestyle modifications (MedDiet and PA). In addition, associations were found between the DNAm studies and BMI, homeostatic model assessment of insulin resistance, monounsaturated fatty acid and polyunsaturated fatty acid, moderate-vigorous PA, fat mass, and adherence to MedDiet | ||
| 520 | |a CONCLUSIONS: It was found that DNAm of genes related to lipid metabolism and inflammation are also present in childhood and that this methylation profile can be modified by interventions based on MedDiet and PA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Inflammatory profile | |
| 650 | 4 | |a Lifestyle modification | |
| 650 | 4 | |a Lipid profile | |
| 650 | 4 | |a Metabolically healthy obesity | |
| 650 | 4 | |a Methylation | |
| 650 | 4 | |a Prepubertal population | |
| 700 | 1 | |a Buonaiuto, Verónica |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz-Moreno, M Isabel |e verfasserin |4 aut | |
| 700 | 1 | |a Vargas-Candela, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Vilches-Perez, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Benitez-Porres, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Romance-Garcia, Angel Ramon |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz-Moreno, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Gomez-Huelgas, Ricardo |e verfasserin |4 aut | |
| 700 | 1 | |a Bernal-Lopez, M Rosa |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical epigenetics |d 2010 |g 12(2020), 1 vom: 23. Sept., Seite 144 |w (DE-627)NLM205276547 |x 1868-7083 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2020 |g number:1 |g day:23 |g month:09 |g pages:144 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/s13148-020-00935-0 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2020 |e 1 |b 23 |c 09 |h 144 | ||