High 18F-FDOPA PET Uptake in Primary Central Nervous System Lymphoma
We present a 42-year-old woman with primary central nervous system lymphoma (PCNSL) and strong F-FDOPA PET uptake. F-FDOPA PET has high diagnostic accuracy in gliomas and brain metastases. The L-type amino acid transporter 1, targeted by F-FDOPA and C-MET PET, is a cell-type transporter usually upregulated in malignant tumors, including PCNSL. In this line, strong uptake was already shown with C-MET in PCNSL. We report the same findings with F-FDOPA. Consequently, PCNSL is a possible differential neoplastic diagnosis of F-FDOPA uptake among neoplastic lesions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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| Enthalten in: |
Clinical nuclear medicine - 46(2021), 1 vom: 01. Jan., Seite e59-e60 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Salgues, Betty [VerfasserIn] |
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| Links: |
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| Themen: |
2C598205QX |
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| Anmerkungen: |
Date Completed 23.12.2020 Date Revised 25.09.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/RLU.0000000000003303 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM315274352 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We present a 42-year-old woman with primary central nervous system lymphoma (PCNSL) and strong F-FDOPA PET uptake. F-FDOPA PET has high diagnostic accuracy in gliomas and brain metastases. The L-type amino acid transporter 1, targeted by F-FDOPA and C-MET PET, is a cell-type transporter usually upregulated in malignant tumors, including PCNSL. In this line, strong uptake was already shown with C-MET in PCNSL. We report the same findings with F-FDOPA. Consequently, PCNSL is a possible differential neoplastic diagnosis of F-FDOPA uptake among neoplastic lesions | ||
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