Choroidal changes in eyes treated with high-dose systemic corticosteroids for optic neuritis
International Journal of Ophthalmology Press..
AIM: To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic neuritis.
METHODS: A retrospective comparative cohort study. Seventy-six eyes of 38 patients with unilateral optic neuritis that received systemic high-dose corticosteroid treatment were enrolled. Choroidal thickness (CT) and choroidal vascularity index (CVI) were measured in both affected and the fellow eyes at baseline, 1wk, 1 and 3mo. Changes in CT and CVI were analyzed in both eyes and compared between eyes.
RESULTS: The mean CT and CVI were 349 µm and 0.70 in the affected eyes and 340 µm and 0.69 in the fellow eyes at baseline (P=0.503 and 0.440, respectively). Decrement of CT and CVI at month 3 were significant in affected eyes (P=0.017 and P<0.001). Decreased CVI began 2wk after treatment whereas CT decreased from 1mo. The CVI also decreased significantly in fellow eyes at 3mo compared to the baseline (P=0.001).
CONCLUSION: A significant decrement in CT and CVI can appear after 3mo in optic neuritis patients treated with high-dose systemic corticosteroid treatment. The decrease in CVI appeared earlier than the decrease in CT, suggesting choroidal vasoconstriction caused by systemic steroid as a possible mechanism.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
International journal of ophthalmology - 13(2020), 9 vom: 16., Seite 1430-1435 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Jun Hyuk [VerfasserIn] |
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| Links: |
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| Themen: |
Choroidal thickness |
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| Anmerkungen: |
Date Revised 28.09.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.18240/ijo.2020.09.15 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM315249226 |
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| 500 | |a Date Revised 28.09.2020 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a International Journal of Ophthalmology Press. | ||
| 520 | |a AIM: To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic neuritis | ||
| 520 | |a METHODS: A retrospective comparative cohort study. Seventy-six eyes of 38 patients with unilateral optic neuritis that received systemic high-dose corticosteroid treatment were enrolled. Choroidal thickness (CT) and choroidal vascularity index (CVI) were measured in both affected and the fellow eyes at baseline, 1wk, 1 and 3mo. Changes in CT and CVI were analyzed in both eyes and compared between eyes | ||
| 520 | |a RESULTS: The mean CT and CVI were 349 µm and 0.70 in the affected eyes and 340 µm and 0.69 in the fellow eyes at baseline (P=0.503 and 0.440, respectively). Decrement of CT and CVI at month 3 were significant in affected eyes (P=0.017 and P<0.001). Decreased CVI began 2wk after treatment whereas CT decreased from 1mo. The CVI also decreased significantly in fellow eyes at 3mo compared to the baseline (P=0.001) | ||
| 520 | |a CONCLUSION: A significant decrement in CT and CVI can appear after 3mo in optic neuritis patients treated with high-dose systemic corticosteroid treatment. The decrease in CVI appeared earlier than the decrease in CT, suggesting choroidal vasoconstriction caused by systemic steroid as a possible mechanism | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Lee, Ji Young |e verfasserin |4 aut | |
| 700 | 1 | |a Ra, Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Nam Yeo |e verfasserin |4 aut | |
| 700 | 1 | |a Baek, Jiwon |e verfasserin |4 aut | |
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