Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus
© 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association..
This study aimed to characterise both neuronal autoantibodies and levels of interferon α, two proposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE). Cerebrospinal fluid (CSF) and plasma from 35 patients with systemic lupus erythematosus (SLE; 15 with NPSLE) showed no antibodies against natively expressed N-methyl-D-aspartate receptors (NMDARs), or the surface of live hippocampal neurons. By comparison to controls (n = 104), patients with SLE had antibodies that bound to a peptide representing the extracellular domain of NMDARs (p < 0.0001), however, binding was retained against both rearranged peptides and no peptide (r = 0.85 and r = 0.79, respectively, p < 0.0001). In summary, neuronal-surface reactive antibodies were not detected in NPSLE. Further, while interferon α levels were higher in SLE (p < 0.0001), they lacked specificity for NPSLE. Our findings mandate a search for novel biomarkers in this condition. ANN NEUROL 2020;88:1244-1250.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:88 |
|---|---|
| Enthalten in: |
Annals of neurology - 88(2020), 6 vom: 20. Dez., Seite 1244-1250 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Varley, James A [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Autoantibodies |
|---|
| Anmerkungen: |
Date Completed 21.12.2020 Date Revised 11.11.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/ana.25908 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM315226323 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM315226323 | ||
| 003 | DE-627 | ||
| 005 | 20231225154443.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ana.25908 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1050.xml |
| 035 | |a (DE-627)NLM315226323 | ||
| 035 | |a (NLM)32951275 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Varley, James A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 21.12.2020 | ||
| 500 | |a Date Revised 11.11.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. | ||
| 520 | |a This study aimed to characterise both neuronal autoantibodies and levels of interferon α, two proposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE). Cerebrospinal fluid (CSF) and plasma from 35 patients with systemic lupus erythematosus (SLE; 15 with NPSLE) showed no antibodies against natively expressed N-methyl-D-aspartate receptors (NMDARs), or the surface of live hippocampal neurons. By comparison to controls (n = 104), patients with SLE had antibodies that bound to a peptide representing the extracellular domain of NMDARs (p < 0.0001), however, binding was retained against both rearranged peptides and no peptide (r = 0.85 and r = 0.79, respectively, p < 0.0001). In summary, neuronal-surface reactive antibodies were not detected in NPSLE. Further, while interferon α levels were higher in SLE (p < 0.0001), they lacked specificity for NPSLE. Our findings mandate a search for novel biomarkers in this condition. ANN NEUROL 2020;88:1244-1250 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Autoantibodies |2 NLM | |
| 650 | 7 | |a Interferon-alpha |2 NLM | |
| 650 | 7 | |a Receptors, N-Methyl-D-Aspartate |2 NLM | |
| 700 | 1 | |a Andersson, Magnus |e verfasserin |4 aut | |
| 700 | 1 | |a Grant, Eleanor |e verfasserin |4 aut | |
| 700 | 1 | |a Berretta, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Zandi, Michael S |e verfasserin |4 aut | |
| 700 | 1 | |a Bondet, Vincent |e verfasserin |4 aut | |
| 700 | 1 | |a Duffy, Darragh |e verfasserin |4 aut | |
| 700 | 1 | |a Hunt, David |e verfasserin |4 aut | |
| 700 | 1 | |a Piehl, Fredrik |e verfasserin |4 aut | |
| 700 | 1 | |a Waters, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Irani, Sarosh R |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of neurology |d 1983 |g 88(2020), 6 vom: 20. Dez., Seite 1244-1250 |w (DE-627)NLM000198420 |x 1531-8249 |7 nnns |
| 773 | 1 | 8 | |g volume:88 |g year:2020 |g number:6 |g day:20 |g month:12 |g pages:1244-1250 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/ana.25908 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 88 |j 2020 |e 6 |b 20 |c 12 |h 1244-1250 | ||