Epidemiological and clinical characteristics of children with acute respiratory viral infections in the Philippines : a prospective cohort study
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: Viral acute respiratory infection (ARI) remains a major global health problem, especially among children in low- and middle-income countries. The study was conducted to reveal aetiological significance of respiratory viruses among both non-hospitalized and hospitalized children.
METHODS: A cohort study of children with ARI at the household, primary healthcare facility, and hospital levels was conducted alongside a hospital-based study including non-cohort children from 2014 to 2016 in the Philippines. The ARI cases were recorded at households and healthcare facilities, and a clinical investigation was performed. Nasopharyngeal swabs were collected from the symptomatic children and tested for respiratory viruses via polymerase chain reaction. Then, the association between healthcare facility utilization and viral detection was investigated.
RESULTS: Overall, 18,514 ARI cases were enrolled in the cohort study, and samples were collected from 4735 of these cases. The hospital-based study detected 648 ARI cases, all of which were sampled. Rhinovirus (22.2%; 1052/4735) was most frequently detected followed by respiratory syncytial virus (12.0%; 566/4735). Enterovirus (adjusted odds ratio, 1.8; 95% confidence interval, 1.1-2.8), human metapneumovirus (2.1, 1.4-3.2), rhinovirus (2.1, 1.8-2.6), and respiratory syncytial virus (1.6, 1.2-1.9) were significantly more prevalent in the ARI cases at healthcare facilities than in those in households. Of all ARI cases, 0.6% required hospitalization while 1.8% were hospitalized among the respiratory syncytial virus-positive cases (3.8, 3.0-4.9).
CONCLUSIONS: We determined the prevalence of respiratory viruses among children with ARIs at the household, primary healthcare facility, and hospital levels and the association with clinical characteristics. In particular, we discovered a significant disease burden and impact of respiratory syncytial virus infections as well as a considerable aetiological implication of rhinovirus infections.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 27(2021), 7 vom: 01. Juli, Seite 1037.e9-1037.e14 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Furuse, Yuki [VerfasserIn] |
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| Links: |
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| Themen: |
Acute respiratory infections |
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| Anmerkungen: |
Date Completed 01.11.2021 Date Revised 01.11.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cmi.2020.09.017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM315220759 |
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| 100 | 1 | |a Furuse, Yuki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Epidemiological and clinical characteristics of children with acute respiratory viral infections in the Philippines |b a prospective cohort study |
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| 500 | |a Date Completed 01.11.2021 | ||
| 500 | |a Date Revised 01.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVES: Viral acute respiratory infection (ARI) remains a major global health problem, especially among children in low- and middle-income countries. The study was conducted to reveal aetiological significance of respiratory viruses among both non-hospitalized and hospitalized children | ||
| 520 | |a METHODS: A cohort study of children with ARI at the household, primary healthcare facility, and hospital levels was conducted alongside a hospital-based study including non-cohort children from 2014 to 2016 in the Philippines. The ARI cases were recorded at households and healthcare facilities, and a clinical investigation was performed. Nasopharyngeal swabs were collected from the symptomatic children and tested for respiratory viruses via polymerase chain reaction. Then, the association between healthcare facility utilization and viral detection was investigated | ||
| 520 | |a RESULTS: Overall, 18,514 ARI cases were enrolled in the cohort study, and samples were collected from 4735 of these cases. The hospital-based study detected 648 ARI cases, all of which were sampled. Rhinovirus (22.2%; 1052/4735) was most frequently detected followed by respiratory syncytial virus (12.0%; 566/4735). Enterovirus (adjusted odds ratio, 1.8; 95% confidence interval, 1.1-2.8), human metapneumovirus (2.1, 1.4-3.2), rhinovirus (2.1, 1.8-2.6), and respiratory syncytial virus (1.6, 1.2-1.9) were significantly more prevalent in the ARI cases at healthcare facilities than in those in households. Of all ARI cases, 0.6% required hospitalization while 1.8% were hospitalized among the respiratory syncytial virus-positive cases (3.8, 3.0-4.9) | ||
| 520 | |a CONCLUSIONS: We determined the prevalence of respiratory viruses among children with ARIs at the household, primary healthcare facility, and hospital levels and the association with clinical characteristics. In particular, we discovered a significant disease burden and impact of respiratory syncytial virus infections as well as a considerable aetiological implication of rhinovirus infections | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute respiratory infections | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Philippines | |
| 650 | 4 | |a Respiratory syncytial virus | |
| 650 | 4 | |a Rhinovirus | |
| 650 | 4 | |a Viral infections | |
| 700 | 1 | |a Tamaki, Raita |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Kamigaki, Taro |e verfasserin |4 aut | |
| 700 | 1 | |a Okamoto, Michiko |e verfasserin |4 aut | |
| 700 | 1 | |a Saito-Obata, Mariko |e verfasserin |4 aut | |
| 700 | 1 | |a Nakagawa, Emiko |e verfasserin |4 aut | |
| 700 | 1 | |a Saito, Mayuko |e verfasserin |4 aut | |
| 700 | 1 | |a Segubre-Mercado, Edelwisa |e verfasserin |4 aut | |
| 700 | 1 | |a Tallo, Veronica |e verfasserin |4 aut | |
| 700 | 1 | |a Lupisan, Socorro |e verfasserin |4 aut | |
| 700 | 1 | |a Oshitani, Hitoshi |e verfasserin |4 aut | |
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