Comparison of COVID-19 disease between young and elderly patients : Hidden viral shedding of COVID-19
Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved..
OBJECTIVES: The symptoms of Coronavirus disease 2019 (COVID-19) vary among patients. The aim of this study was to investigate the clinical manifestation and disease duration in young versus elderly patients.
METHODS: We retrospectively analyzed 187 patients (87 elderly and 100 young patients) with confirmed COVID-19. The clinical characteristics and chest computed tomography (CT) extent as defined by a score were compared between the two groups.
RESULTS: The numbers of asymptomatic cases and severe cases were significantly higher in the elderly group (elderly group vs. young group; asymptomatic cases, 31 [35.6%] vs. 10 [10%], p < 0.0001; severe cases, 25 [28.7%] vs. 8 [8.0%], p = 0.0002). The proportion of asymptomatic patients and severe patients increased across the 10-year age groups. There was no significant difference in the total CT score and number of abnormal cases. A significant positive correlation between the disease duration and patient age was observed in asymptomatic patients (ρ = 0.4570, 95% CI 0.1198-0.6491, p = 0.0034).
CONCLUSIONS: Although the extent of lung involvement did not have a significant difference between the young and elderly patients, elderly patients were more likely to have severe clinical manifestations. Elderly patients were also more likely to be asymptomatic and a source of COVID-19 viral shedding.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 27(2021), 1 vom: 30. Jan., Seite 70-75 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mori, Hitoshi [VerfasserIn] |
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| Links: |
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| Themen: |
Asymptomatic patients |
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| Anmerkungen: |
Date Completed 23.11.2020 Date Revised 27.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jiac.2020.09.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM315217618 |
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| 245 | 1 | 0 | |a Comparison of COVID-19 disease between young and elderly patients |b Hidden viral shedding of COVID-19 |
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| 500 | |a Date Revised 27.04.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a OBJECTIVES: The symptoms of Coronavirus disease 2019 (COVID-19) vary among patients. The aim of this study was to investigate the clinical manifestation and disease duration in young versus elderly patients | ||
| 520 | |a METHODS: We retrospectively analyzed 187 patients (87 elderly and 100 young patients) with confirmed COVID-19. The clinical characteristics and chest computed tomography (CT) extent as defined by a score were compared between the two groups | ||
| 520 | |a RESULTS: The numbers of asymptomatic cases and severe cases were significantly higher in the elderly group (elderly group vs. young group; asymptomatic cases, 31 [35.6%] vs. 10 [10%], p < 0.0001; severe cases, 25 [28.7%] vs. 8 [8.0%], p = 0.0002). The proportion of asymptomatic patients and severe patients increased across the 10-year age groups. There was no significant difference in the total CT score and number of abnormal cases. A significant positive correlation between the disease duration and patient age was observed in asymptomatic patients (ρ = 0.4570, 95% CI 0.1198-0.6491, p = 0.0034) | ||
| 520 | |a CONCLUSIONS: Although the extent of lung involvement did not have a significant difference between the young and elderly patients, elderly patients were more likely to have severe clinical manifestations. Elderly patients were also more likely to be asymptomatic and a source of COVID-19 viral shedding | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Asymptomatic patients | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Clinical characteristics | |
| 650 | 4 | |a Elderly patients | |
| 650 | 4 | |a Young patients | |
| 700 | 1 | |a Obinata, Hirofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Murakami, Wakana |e verfasserin |4 aut | |
| 700 | 1 | |a Tatsuya, Kodama |e verfasserin |4 aut | |
| 700 | 1 | |a Sasaki, Hisashi |e verfasserin |4 aut | |
| 700 | 1 | |a Miyake, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Taniguchi, Yasuaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ota, Shinichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaga, Mitsuki |e verfasserin |4 aut | |
| 700 | 1 | |a Suyama, Yohsuke |e verfasserin |4 aut | |
| 700 | 1 | |a Tamura, Kaku |e verfasserin |4 aut | |
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