Effects of the herbal preparation STW 5-II on in vitro muscle activity in the guinea pig stomach
© 2020 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd..
BACKGROUND: STW 5 is a combination of nine medicinal herbal extracts and used to treat functional gastrointestinal disorders including functional dyspepsia. It has a region-specific effect by relaxing the proximal and contracting the distal stomach. The research combination STW 5-II (Iberogast® Advance) lacks three herbal extracts but seems clinically as effective as STW 5. However, the action of STW 5-II on gastric motility is unknown.
METHODS: In vitro circular and longitudinal muscle tone and contractility were recorded from guinea pig gastric fundus and antrum with isometric force transducers.
KEY RESULTS: STW 5-II decreased concentration-dependently (64-512 µg/ml) the tone of circular and longitudinal muscle strips from the fundus. In contrast, STW 5-II increased concentration-dependently contraction amplitude in antral circular and longitudinal muscle. The effects were region-dependent but comparable in the two muscle layers. Application of 512 µg STW 5 or STW 5-II revealed comparable effects in the fundus and antrum circular and longitudinal muscle strips.
CONCLUSIONS AND INTERFERENCES: STW 5-II had a region-specific effect and relaxed the proximal stomach but increased the contractility in the antrum. It was as effective as STW 5 which may explain its comparable clinical effects in treating functional dyspepsia. Impaired accommodation may be normalized through relaxation of the fundus, while the motility-promoting effects leading to an increase in antral motility may activate the gastric pump.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
|---|---|
| Enthalten in: |
Neurogastroenterology and motility - 33(2021), 2 vom: 02. Feb., Seite e13984 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Schemann, Michael [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Functional dyspepsia |
|---|
| Anmerkungen: |
Date Completed 01.11.2021 Date Revised 01.11.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/nmo.13984 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM315083557 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM315083557 | ||
| 003 | DE-627 | ||
| 005 | 20231225154137.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/nmo.13984 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1050.xml |
| 035 | |a (DE-627)NLM315083557 | ||
| 035 | |a (NLM)32936513 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Schemann, Michael |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of the herbal preparation STW 5-II on in vitro muscle activity in the guinea pig stomach |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 01.11.2021 | ||
| 500 | |a Date Revised 01.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: STW 5 is a combination of nine medicinal herbal extracts and used to treat functional gastrointestinal disorders including functional dyspepsia. It has a region-specific effect by relaxing the proximal and contracting the distal stomach. The research combination STW 5-II (Iberogast® Advance) lacks three herbal extracts but seems clinically as effective as STW 5. However, the action of STW 5-II on gastric motility is unknown | ||
| 520 | |a METHODS: In vitro circular and longitudinal muscle tone and contractility were recorded from guinea pig gastric fundus and antrum with isometric force transducers | ||
| 520 | |a KEY RESULTS: STW 5-II decreased concentration-dependently (64-512 µg/ml) the tone of circular and longitudinal muscle strips from the fundus. In contrast, STW 5-II increased concentration-dependently contraction amplitude in antral circular and longitudinal muscle. The effects were region-dependent but comparable in the two muscle layers. Application of 512 µg STW 5 or STW 5-II revealed comparable effects in the fundus and antrum circular and longitudinal muscle strips | ||
| 520 | |a CONCLUSIONS AND INTERFERENCES: STW 5-II had a region-specific effect and relaxed the proximal stomach but increased the contractility in the antrum. It was as effective as STW 5 which may explain its comparable clinical effects in treating functional dyspepsia. Impaired accommodation may be normalized through relaxation of the fundus, while the motility-promoting effects leading to an increase in antral motility may activate the gastric pump | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a STW 5 | |
| 650 | 4 | |a STW 5-II | |
| 650 | 4 | |a functional dyspepsia | |
| 650 | 4 | |a gastric motility | |
| 650 | 4 | |a phytotherapy | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
| 650 | 7 | |a iberogast |2 NLM | |
| 700 | 1 | |a Landmann, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Kelber, O |e verfasserin |4 aut | |
| 700 | 1 | |a Ammar, Ramy M |e verfasserin |4 aut | |
| 700 | 1 | |a Krueger, Dagmar |e verfasserin |4 aut | |
| 700 | 1 | |a Michel, K |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neurogastroenterology and motility |d 1994 |g 33(2021), 2 vom: 02. Feb., Seite e13984 |w (DE-627)NLM075187337 |x 1365-2982 |7 nnns |
| 773 | 1 | 8 | |g volume:33 |g year:2021 |g number:2 |g day:02 |g month:02 |g pages:e13984 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/nmo.13984 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 33 |j 2021 |e 2 |b 02 |c 02 |h e13984 | ||