Tracking Smell Loss to Identify Healthcare Workers with SARS-CoV-2 Infection
BACKGROUND: Healthcare workers (HCW) treating COVID-19 patients are at high risk for infection and may also spread infection through their contact with vulnerable patients. Smell loss has been associated with SARS-CoV-2 infection, but it is unknown whether monitoring for smell loss can be used to identify asymptomatic infection among high risk individuals, like HCW.
METHODS: We performed a prospective cohort study, tracking 473 HCW across three months to determine if smell loss could predict SARS-CoV-2 infection in this high-risk group. HCW subjects completed a longitudinal, novel behavioral at-home assessment of smell function with household items, as well as detailed symptom surveys that included a parosmia screening questionnaire, and RT-qPCR testing to identify SARS-CoV-2 infection.
RESULTS: SARS-CoV-2 was identified in 17 (3.6%) of 473 HCW. Among the 17 infected HCW, 53% reported smell loss, and were more likely to report smell loss than COVID-negative HCW on both the at-home assessment and the screening questionnaire (P < .01). 67% reported smell loss prior to having a positive SARS-CoV-2 test, and smell loss was reported a median of two days before testing positive. Neurological symptoms were reported more frequently among COVID-positive HCW who reported smell loss (P < .01).
CONCLUSIONS: In this prospective study of HCW, self-reported changes in smell using two different measures were predictive of COVID-19 infection. Smell loss frequently preceded a positive test and was associated with neurological symptoms.
| Errataetall: |
UpdateIn: PLoS One. 2021 Mar 3;16(3):e0248025. - PMID 33657167 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2020 |
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| Enthalten in: |
medRxiv : the preprint server for health sciences - (2020) vom: 10. Sept. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Weiss, Julian J [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 29.03.2024 published: Electronic UpdateIn: PLoS One. 2021 Mar 3;16(3):e0248025. - PMID 33657167 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1101/2020.09.07.20188813 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM315070048 |
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| 245 | 1 | 0 | |a Tracking Smell Loss to Identify Healthcare Workers with SARS-CoV-2 Infection |
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| 500 | |a UpdateIn: PLoS One. 2021 Mar 3;16(3):e0248025. - PMID 33657167 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Healthcare workers (HCW) treating COVID-19 patients are at high risk for infection and may also spread infection through their contact with vulnerable patients. Smell loss has been associated with SARS-CoV-2 infection, but it is unknown whether monitoring for smell loss can be used to identify asymptomatic infection among high risk individuals, like HCW | ||
| 520 | |a METHODS: We performed a prospective cohort study, tracking 473 HCW across three months to determine if smell loss could predict SARS-CoV-2 infection in this high-risk group. HCW subjects completed a longitudinal, novel behavioral at-home assessment of smell function with household items, as well as detailed symptom surveys that included a parosmia screening questionnaire, and RT-qPCR testing to identify SARS-CoV-2 infection | ||
| 520 | |a RESULTS: SARS-CoV-2 was identified in 17 (3.6%) of 473 HCW. Among the 17 infected HCW, 53% reported smell loss, and were more likely to report smell loss than COVID-negative HCW on both the at-home assessment and the screening questionnaire (P < .01). 67% reported smell loss prior to having a positive SARS-CoV-2 test, and smell loss was reported a median of two days before testing positive. Neurological symptoms were reported more frequently among COVID-positive HCW who reported smell loss (P < .01) | ||
| 520 | |a CONCLUSIONS: In this prospective study of HCW, self-reported changes in smell using two different measures were predictive of COVID-19 infection. Smell loss frequently preceded a positive test and was associated with neurological symptoms | ||
| 650 | 4 | |a Preprint | |
| 700 | 1 | |a Attuquayefio, Tuki N |e verfasserin |4 aut | |
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| 700 | 1 | |a Li, Fangyong |e verfasserin |4 aut | |
| 700 | 1 | |a Herz, Rachel S |e verfasserin |4 aut | |
| 700 | 1 | |a White, Theresa L |e verfasserin |4 aut | |
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| 700 | 1 | |a Geng, Bertie |e verfasserin |4 aut | |
| 700 | 1 | |a Datta, Rupak |e verfasserin |4 aut | |
| 700 | 1 | |a Wyllie, Anne L |e verfasserin |4 aut | |
| 700 | 1 | |a Grubaugh, Nathan D |e verfasserin |4 aut | |
| 700 | 1 | |a Casanovas-Massana, Arnau |e verfasserin |4 aut | |
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