Origins and Evolutionary Patterns of the 1.688 Satellite DNA Family in Drosophila Phylogeny
Copyright © 2020 de Lima et al..
Satellite DNAs (satDNAs) are a ubiquitous feature of eukaryotic genomes and are usually the major components of constitutive heterochromatin. The 1.688 satDNA, also known as the 359 bp satellite, is one of the most abundant repetitive sequences in Drosophila melanogaster and has been linked to several different biological functions. We investigated the presence and evolution of the 1.688 satDNA in 16 Drosophila genomes. We find that the 1.688 satDNA family is much more ancient than previously appreciated, being shared among part of the melanogaster group that diverged from a common ancestor ∼27 Mya. We found that the 1.688 satDNA family has two major subfamilies spread throughout Drosophila phylogeny (∼360 bp and ∼190 bp). Phylogenetic analysis of ∼10,000 repeats extracted from 14 of the species revealed that the 1.688 satDNA family is present within heterochromatin and euchromatin. A high number of euchromatic repeats are gene proximal, suggesting the potential for local gene regulation. Notably, heterochromatic copies display concerted evolution and a species-specific pattern, whereas euchromatic repeats display a more typical evolutionary pattern, suggesting that chromatin domains may influence the evolution of these sequences. Overall, our data indicate the 1.688 satDNA as the most perduring satDNA family described in Drosophila phylogeny to date. Our study provides a strong foundation for future work on the functional roles of 1.688 satDNA across many Drosophila species.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
|---|---|
| Enthalten in: |
G3 (Bethesda, Md.) - 10(2020), 11 vom: 05. Nov., Seite 4129-4146 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
de Lima, Leonardo G [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
1.688 |
|---|
| Anmerkungen: |
Date Completed 21.06.2021 Date Revised 30.03.2024 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1534/g3.120.401727 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM315059192 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM315059192 | ||
| 003 | DE-627 | ||
| 005 | 20240330232851.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1534/g3.120.401727 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1356.xml |
| 035 | |a (DE-627)NLM315059192 | ||
| 035 | |a (NLM)32934018 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a de Lima, Leonardo G |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Origins and Evolutionary Patterns of the 1.688 Satellite DNA Family in Drosophila Phylogeny |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 21.06.2021 | ||
| 500 | |a Date Revised 30.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 de Lima et al. | ||
| 520 | |a Satellite DNAs (satDNAs) are a ubiquitous feature of eukaryotic genomes and are usually the major components of constitutive heterochromatin. The 1.688 satDNA, also known as the 359 bp satellite, is one of the most abundant repetitive sequences in Drosophila melanogaster and has been linked to several different biological functions. We investigated the presence and evolution of the 1.688 satDNA in 16 Drosophila genomes. We find that the 1.688 satDNA family is much more ancient than previously appreciated, being shared among part of the melanogaster group that diverged from a common ancestor ∼27 Mya. We found that the 1.688 satDNA family has two major subfamilies spread throughout Drosophila phylogeny (∼360 bp and ∼190 bp). Phylogenetic analysis of ∼10,000 repeats extracted from 14 of the species revealed that the 1.688 satDNA family is present within heterochromatin and euchromatin. A high number of euchromatic repeats are gene proximal, suggesting the potential for local gene regulation. Notably, heterochromatic copies display concerted evolution and a species-specific pattern, whereas euchromatic repeats display a more typical evolutionary pattern, suggesting that chromatin domains may influence the evolution of these sequences. Overall, our data indicate the 1.688 satDNA as the most perduring satDNA family described in Drosophila phylogeny to date. Our study provides a strong foundation for future work on the functional roles of 1.688 satDNA across many Drosophila species | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a 1.688 | |
| 650 | 4 | |a 359 bp satellite | |
| 650 | 4 | |a Drosophila melanogaster group | |
| 650 | 4 | |a Satellite DNA | |
| 650 | 4 | |a concerted evolution | |
| 650 | 4 | |a heterochromatin | |
| 650 | 7 | |a DNA, Satellite |2 NLM | |
| 700 | 1 | |a Hanlon, Stacey L |e verfasserin |4 aut | |
| 700 | 1 | |a Gerton, Jennifer L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t G3 (Bethesda, Md.) |d 2011 |g 10(2020), 11 vom: 05. Nov., Seite 4129-4146 |w (DE-627)NLM215888499 |x 2160-1836 |7 nnns |
| 773 | 1 | 8 | |g volume:10 |g year:2020 |g number:11 |g day:05 |g month:11 |g pages:4129-4146 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1534/g3.120.401727 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 10 |j 2020 |e 11 |b 05 |c 11 |h 4129-4146 | ||