Drp1-dependent mitochondrial fission in cardiovascular disease
Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to modulate their morphology, distribution, and function, which are referred as 'mitochondrial dynamics'. Dynamin-related protein 1 (Drp1) is known as the major pro-fission protein whose activity is tightly regulated to clear the damaged mitochondria via mitophagy, ensuring a strict control over the intricate process of cellular and organ dynamics in heart. Various posttranslational modifications (PTMs) of Drp1 have been identified including phosphorylation, SUMOylation, palmitoylation, ubiquitination, S-nitrosylation, and O-GlcNAcylation, which implicate a role in the regulation of mitochondrial dynamics. An intact mitochondrial homeostasis is critical for heart to fuel contractile function and cardiomyocyte metabolism, while defects in mitochondrial dynamics constitute an essential part of the pathophysiology underlying various cardiovascular diseases (CVDs). In this review, we summarize current knowledge on the critical role of Drp1 in the pathogenesis of CVDs including endothelial dysfunction, smooth muscle remodeling, cardiac hypertrophy, pulmonary arterial hypertension, myocardial ischemia-reperfusion, and myocardial infarction. We also highlight how the targeting of Drp1 could potentially contribute to CVDs treatments.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
---|---|
Enthalten in: |
Acta pharmacologica Sinica - 42(2021), 5 vom: 10. Mai, Seite 655-664 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Jin, Jia-Yu [VerfasserIn] |
---|
Links: |
---|
Themen: |
Cardiotonic Agents |
---|
Anmerkungen: |
Date Completed 27.09.2021 Date Revised 03.05.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1038/s41401-020-00518-y |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM314854592 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM314854592 | ||
003 | DE-627 | ||
005 | 20231225153633.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1038/s41401-020-00518-y |2 doi | |
028 | 5 | 2 | |a pubmed24n1049.xml |
035 | |a (DE-627)NLM314854592 | ||
035 | |a (NLM)32913266 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Jin, Jia-Yu |e verfasserin |4 aut | |
245 | 1 | 0 | |a Drp1-dependent mitochondrial fission in cardiovascular disease |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 27.09.2021 | ||
500 | |a Date Revised 03.05.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to modulate their morphology, distribution, and function, which are referred as 'mitochondrial dynamics'. Dynamin-related protein 1 (Drp1) is known as the major pro-fission protein whose activity is tightly regulated to clear the damaged mitochondria via mitophagy, ensuring a strict control over the intricate process of cellular and organ dynamics in heart. Various posttranslational modifications (PTMs) of Drp1 have been identified including phosphorylation, SUMOylation, palmitoylation, ubiquitination, S-nitrosylation, and O-GlcNAcylation, which implicate a role in the regulation of mitochondrial dynamics. An intact mitochondrial homeostasis is critical for heart to fuel contractile function and cardiomyocyte metabolism, while defects in mitochondrial dynamics constitute an essential part of the pathophysiology underlying various cardiovascular diseases (CVDs). In this review, we summarize current knowledge on the critical role of Drp1 in the pathogenesis of CVDs including endothelial dysfunction, smooth muscle remodeling, cardiac hypertrophy, pulmonary arterial hypertension, myocardial ischemia-reperfusion, and myocardial infarction. We also highlight how the targeting of Drp1 could potentially contribute to CVDs treatments | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Drp1 | |
650 | 4 | |a cardiovascular diseases | |
650 | 4 | |a mitochondrial fission | |
650 | 4 | |a mitophagy | |
650 | 4 | |a posttranslational modifications | |
650 | 7 | |a Cardiotonic Agents |2 NLM | |
650 | 7 | |a Enzyme Inhibitors |2 NLM | |
650 | 7 | |a Dynamins |2 NLM | |
650 | 7 | |a EC 3.6.5.5 |2 NLM | |
700 | 1 | |a Wei, Xiang-Xiang |e verfasserin |4 aut | |
700 | 1 | |a Zhi, Xiu-Ling |e verfasserin |4 aut | |
700 | 1 | |a Wang, Xin-Hong |e verfasserin |4 aut | |
700 | 1 | |a Meng, Dan |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Acta pharmacologica Sinica |d 2000 |g 42(2021), 5 vom: 10. Mai, Seite 655-664 |w (DE-627)NLM111735181 |x 1745-7254 |7 nnns |
773 | 1 | 8 | |g volume:42 |g year:2021 |g number:5 |g day:10 |g month:05 |g pages:655-664 |
856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41401-020-00518-y |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 42 |j 2021 |e 5 |b 10 |c 05 |h 655-664 |