Immunohistochemical basigin expression level in thyroid cancer tissues
BACKGROUND: Thyroid cancer (TC) is the most common endocrine malignancy; basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify the change of BSG expression in TC and its possible potential mechanism.
METHODS: The BSG expression levels in TC were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays, and literatures. Integrated analysis was performed to determined BSG expression levels in TC comprehensively. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed with the integration of BSG co-expressed genes and differentially expressed genes (DEGs) in TC tissues to explore the potential mechanisms of BSG in TC.
RESULTS: The protein expression level of BSG was significantly higher in TC cases based on the IHC experiments. In addition, the combined SMD for BSG expression was 0.39 (p < 0.0001), the diagnostic odds ratio was 3.69, and the AUC of the sROC curve was 0.6986 using 1182 TC cases and 437 non-cancerous cases from 17 independent datasets. Furthermore, BSG co-expressed genes tended to be enriched in gene terms of the extracellular matrix (ECM), cell adhesion, and cell-cell interactions. The expression levels of nine hub BSG co-expressed genes were markedly upregulated in TC cases.
CONCLUSION: BSG expression levels were closely correlated with the progression of TC and may affect the signals of the ECM, cell adhesion, and cell-cell interactions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
World journal of surgical oncology - 18(2020), 1 vom: 05. Sept., Seite 240 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guo, Wan-Ping [VerfasserIn] |
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| Links: |
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| Themen: |
136894-56-9 |
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| Anmerkungen: |
Date Completed 14.05.2021 Date Revised 14.05.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12957-020-01975-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314638954 |
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| 245 | 1 | 0 | |a Immunohistochemical basigin expression level in thyroid cancer tissues |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Thyroid cancer (TC) is the most common endocrine malignancy; basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify the change of BSG expression in TC and its possible potential mechanism | ||
| 520 | |a METHODS: The BSG expression levels in TC were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays, and literatures. Integrated analysis was performed to determined BSG expression levels in TC comprehensively. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed with the integration of BSG co-expressed genes and differentially expressed genes (DEGs) in TC tissues to explore the potential mechanisms of BSG in TC | ||
| 520 | |a RESULTS: The protein expression level of BSG was significantly higher in TC cases based on the IHC experiments. In addition, the combined SMD for BSG expression was 0.39 (p < 0.0001), the diagnostic odds ratio was 3.69, and the AUC of the sROC curve was 0.6986 using 1182 TC cases and 437 non-cancerous cases from 17 independent datasets. Furthermore, BSG co-expressed genes tended to be enriched in gene terms of the extracellular matrix (ECM), cell adhesion, and cell-cell interactions. The expression levels of nine hub BSG co-expressed genes were markedly upregulated in TC cases | ||
| 520 | |a CONCLUSION: BSG expression levels were closely correlated with the progression of TC and may affect the signals of the ECM, cell adhesion, and cell-cell interactions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Basigin | |
| 650 | 4 | |a RNA-sequencing | |
| 650 | 4 | |a Thyroid cancer | |
| 650 | 4 | |a Thyroid papillary carcinoma | |
| 650 | 4 | |a Tissue microarray | |
| 650 | 7 | |a Basigin |2 NLM | |
| 650 | 7 | |a 136894-56-9 |2 NLM | |
| 700 | 1 | |a Tang, Deng |e verfasserin |4 aut | |
| 700 | 1 | |a Pang, Yu-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiao-Jiao |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Zhi-Guang |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Xiao-Zhun |e verfasserin |4 aut | |
| 700 | 1 | |a Lai, Qin-Qiao |e verfasserin |4 aut | |
| 700 | 1 | |a Gan, Jin-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Xiao-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiao-Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Zhi-Xiao |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Wei |e verfasserin |4 aut | |
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