Ubiquitin, Autophagy and Neurodegenerative Diseases
Ubiquitin signals play various roles in proteolytic and non-proteolytic functions. Ubiquitin signals are recognized as targets of the ubiquitin-proteasome system and the autophagy-lysosome pathway. In autophagy, ubiquitin signals are required for selective incorporation of cargoes, such as proteins, organelles, and microbial invaders, into autophagosomes. Autophagy receptors possessing an LC3-binding domain and a ubiquitin binding domain are involved in this process. Autophagy activity can decline as a result of genetic variation, aging, or lifestyle, resulting in the onset of various neurodegenerative diseases. This review summarizes the selective autophagy of neurodegenerative disease-associated protein aggregates via autophagy receptors and discusses its therapeutic application for neurodegenerative diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Cells - 9(2020), 9 vom: 02. Sept. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Watanabe, Yoshihisa [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 25.03.2021 Date Revised 25.03.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/cells9092022 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314601902 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Ubiquitin signals play various roles in proteolytic and non-proteolytic functions. Ubiquitin signals are recognized as targets of the ubiquitin-proteasome system and the autophagy-lysosome pathway. In autophagy, ubiquitin signals are required for selective incorporation of cargoes, such as proteins, organelles, and microbial invaders, into autophagosomes. Autophagy receptors possessing an LC3-binding domain and a ubiquitin binding domain are involved in this process. Autophagy activity can decline as a result of genetic variation, aging, or lifestyle, resulting in the onset of various neurodegenerative diseases. This review summarizes the selective autophagy of neurodegenerative disease-associated protein aggregates via autophagy receptors and discusses its therapeutic application for neurodegenerative diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a autophagy | |
| 650 | 4 | |a autophagy–lysosome pathway | |
| 650 | 4 | |a neurodegenerative diseases | |
| 650 | 4 | |a ubiquitin | |
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| 650 | 7 | |a Cell Cycle Proteins |2 NLM | |
| 650 | 7 | |a Membrane Transport Proteins |2 NLM | |
| 650 | 7 | |a OPTN protein, human |2 NLM | |
| 650 | 7 | |a SQSTM1 protein, human |2 NLM | |
| 650 | 7 | |a Sequestosome-1 Protein |2 NLM | |
| 650 | 7 | |a Ubiquitin |2 NLM | |
| 650 | 7 | |a Ubiquitin-Protein Ligases |2 NLM | |
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| 700 | 1 | |a Tanaka, Masaki |e verfasserin |4 aut | |
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