A connectome and analysis of the adult Drosophila central brain
© 2020, Scheffer et al..
The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly's brain.
Errataetall: | |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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Enthalten in: |
eLife - 9(2020) vom: 07. Sept. |
Sprache: |
Englisch |
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Beteiligte Personen: |
Scheffer, Louis K [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 23.02.2021 Date Revised 11.02.2024 published: Electronic CommentIn: Elife. 2020 Oct 08;9:. - PMID 33030427 Citation Status MEDLINE |
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doi: |
10.7554/eLife.57443 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM314533044 |
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100 | 1 | |a Scheffer, Louis K |e verfasserin |4 aut | |
245 | 1 | 2 | |a A connectome and analysis of the adult Drosophila central brain |
264 | 1 | |c 2020 | |
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337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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500 | |a Date Completed 23.02.2021 | ||
500 | |a Date Revised 11.02.2024 | ||
500 | |a published: Electronic | ||
500 | |a CommentIn: Elife. 2020 Oct 08;9:. - PMID 33030427 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2020, Scheffer et al. | ||
520 | |a The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly's brain | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Systematic Review | |
650 | 4 | |a D. melanogaster | |
650 | 4 | |a brain regions | |
650 | 4 | |a cell types | |
650 | 4 | |a computational biology | |
650 | 4 | |a connectome | |
650 | 4 | |a connectome reconstuction methods | |
650 | 4 | |a graph properties | |
650 | 4 | |a neuroscience | |
650 | 4 | |a synapse detecton | |
650 | 4 | |a systems biology | |
700 | 1 | |a Xu, C Shan |e verfasserin |4 aut | |
700 | 1 | |a Januszewski, Michal |e verfasserin |4 aut | |
700 | 1 | |a Lu, Zhiyuan |e verfasserin |4 aut | |
700 | 1 | |a Takemura, Shin-Ya |e verfasserin |4 aut | |
700 | 1 | |a Hayworth, Kenneth J |e verfasserin |4 aut | |
700 | 1 | |a Huang, Gary B |e verfasserin |4 aut | |
700 | 1 | |a Shinomiya, Kazunori |e verfasserin |4 aut | |
700 | 1 | |a Maitlin-Shepard, Jeremy |e verfasserin |4 aut | |
700 | 1 | |a Berg, Stuart |e verfasserin |4 aut | |
700 | 1 | |a Clements, Jody |e verfasserin |4 aut | |
700 | 1 | |a Hubbard, Philip M |e verfasserin |4 aut | |
700 | 1 | |a Katz, William T |e verfasserin |4 aut | |
700 | 1 | |a Umayam, Lowell |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Ting |e verfasserin |4 aut | |
700 | 1 | |a Ackerman, David |e verfasserin |4 aut | |
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700 | 1 | |a Dolafi, Tom |e verfasserin |4 aut | |
700 | 1 | |a Kainmueller, Dagmar |e verfasserin |4 aut | |
700 | 1 | |a Kawase, Takashi |e verfasserin |4 aut | |
700 | 1 | |a Khairy, Khaled A |e verfasserin |4 aut | |
700 | 1 | |a Leavitt, Laramie |e verfasserin |4 aut | |
700 | 1 | |a Li, Peter H |e verfasserin |4 aut | |
700 | 1 | |a Lindsey, Larry |e verfasserin |4 aut | |
700 | 1 | |a Neubarth, Nicole |e verfasserin |4 aut | |
700 | 1 | |a Olbris, Donald J |e verfasserin |4 aut | |
700 | 1 | |a Otsuna, Hideo |e verfasserin |4 aut | |
700 | 1 | |a Trautman, Eric T |e verfasserin |4 aut | |
700 | 1 | |a Ito, Masayoshi |e verfasserin |4 aut | |
700 | 1 | |a Bates, Alexander S |e verfasserin |4 aut | |
700 | 1 | |a Goldammer, Jens |e verfasserin |4 aut | |
700 | 1 | |a Wolff, Tanya |e verfasserin |4 aut | |
700 | 1 | |a Svirskas, Robert |e verfasserin |4 aut | |
700 | 1 | |a Schlegel, Philipp |e verfasserin |4 aut | |
700 | 1 | |a Neace, Erika |e verfasserin |4 aut | |
700 | 1 | |a Knecht, Christopher J |e verfasserin |4 aut | |
700 | 1 | |a Alvarado, Chelsea X |e verfasserin |4 aut | |
700 | 1 | |a Bailey, Dennis A |e verfasserin |4 aut | |
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700 | 1 | |a Borycz, Jolanta A |e verfasserin |4 aut | |
700 | 1 | |a Canino, Brandon S |e verfasserin |4 aut | |
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700 | 1 | |a Cook, Michael |e verfasserin |4 aut | |
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700 | 1 | |a Hopkins, Gary Patrick |e verfasserin |4 aut | |
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700 | 1 | |a Kim, SungJin |e verfasserin |4 aut | |
700 | 1 | |a Kirk, Nicole A |e verfasserin |4 aut | |
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700 | 1 | |a Jefferis, Gregory Sxe |e verfasserin |4 aut | |
700 | 0 | |a et al |4 oth | |
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